Literature DB >> 10692383

AcrD of Escherichia coli is an aminoglycoside efflux pump.

E Y Rosenberg1, D Ma, H Nikaido.   

Abstract

AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.

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Year:  2000        PMID： 10692383      PMCID： PMC94475          DOI： 10.1128/JB.182.6.1754-1756.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  21 in total

1.  The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE.

Authors:  B Wu; C Georgopoulos; D Ang
Journal:  J Bacteriol       Date:  1992-08       Impact factor: 3.490

Review 2.  Multidrug efflux pumps of gram-negative bacteria.

Authors:  H Nikaido
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

3.  Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.

Authors:  J A Fralick
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

Review 4.  Mechanism of bactericidal action of aminoglycosides.

Authors:  B D Davis
Journal:  Microbiol Rev       Date:  1987-09

5.  AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.

Authors:  H Okusu; D Ma; H Nikaido
Journal:  J Bacteriol       Date:  1996-01       Impact factor: 3.490

6.  Efflux pumps and drug resistance in gram-negative bacteria.

Authors:  D Ma; D N Cook; J E Hearst; H Nikaido
Journal:  Trends Microbiol       Date:  1994-12       Impact factor: 17.079

7.  Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport.

Authors:  M H Saier; R Tam; A Reizer; J Reizer
Journal:  Mol Microbiol       Date:  1994-03       Impact factor: 3.501

8.  Membrane potential and gentamicin uptake in Staphylococcus aureus.

Authors:  S M Mates; E S Eisenberg; L J Mandel; L Patel; H R Kaback; M H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

9.  Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.

Authors:  D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal:  J Bacteriol       Date:  1993-10       Impact factor: 3.490

10.  Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.

Authors:  D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal:  Mol Microbiol       Date:  1995-04       Impact factor: 3.501
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  91 in total

1.  Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.

Authors:  M C Sulavik; C Houseweart; C Cramer; N Jiwani; N Murgolo; J Greene; B DiDomenico; K J Shaw; G H Miller; R Hare; G Shimer
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

2.  Global impact of sdiA amplification revealed by comprehensive gene expression profiling of Escherichia coli.

Authors:  Y Wei; J M Lee; D R Smulski; R A LaRossa
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

3.  Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.

Authors:  S Magnet; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

4.  A resistance-nodulation-cell division family xenobiotic efflux pump in an obligate anaerobe, Porphyromonas gingivalis.

Authors:  Takeshi Ikeda; Fuminobu Yoshimura
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

5.  Stress-based identification and classification of antibacterial agents: second-generation Escherichia coli reporter strains and optimization of detection.

Authors:  Elyse Shapiro; François Baneyx
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

Review 6.  Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex.

Authors:  Feng Long; Chih-Chia Su; Hsiang-Ting Lei; Jani Reddy Bolla; Sylvia V Do; Edward W Yu
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-04-19       Impact factor: 6.237

Review 7.  Vacuuming the periplasm.

Authors:  Olga Lomovskaya; Maxim Totrov
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

Review 8.  Aminoglycoside resistance in Pseudomonas aeruginosa.

Authors:  Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

9.  Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes.

Authors:  Miguel Viveiros; Ana Jesus; Mafalda Brito; Clara Leandro; Marta Martins; Diane Ordway; Ana Maria Molnar; Joseph Molnar; Leonard Amaral
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

10.  Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli.

Authors:  Julio Ramos Aires; Hiroshi Nikaido
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490
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