Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species.

Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngbya majuscula and Schizothrixsp. assemblage collected at Yanuca Island, Fiji. The structures of compounds 1 and 2 were determined by spectroscopic methods. Both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic acid, which has previously been described only as a component of kulolide-1 (3) and kulokainalide-1 (4), metabolites from the marine mollusk Philinopsis speciosa. Thus, the isolation of the yanucamides from this cyanobacterial assemblage supports the hypothesis that the kulolides and related metabolites are of cyanobacterial origin.