Literature DB >> 1068482

Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

G Kent, S Gay, T Inouye, R Bahu, O T Minick, H Popper.   

Abstract

Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.

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Year:  1976        PMID： 1068482      PMCID： PMC431190          DOI： 10.1073/pnas.73.10.3719

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

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  70 in total

1.  CYP11B2 expression in HSCs and its effect on hepatic fibrogenesis.

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Journal:  World J Gastroenterol       Date:  2000-12       Impact factor: 5.742

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9.  Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats.

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10.  Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.

Authors:  D C Rockey; C N Housset; S L Friedman
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808
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