Literature DB >> 4416771

Ultrastructural changes in livers of two patients with hypervitaminosis A.

Z Hruban, R M Russell, J L Boyer, S Glagov, S A Bagheri.   

Abstract

The principal distinctive ultrastructural changes observed in the livers of 2 patients with chronic hypervitaminosis A were perisinusoidal fibrosis and massive accumulation of lipid-storing cells (Ito cells). The fibrosis consisted of a network of basement membranes with numerous bundles of collagen and reticulum fibrils. This network contained numerous Ito cells, and moderate numbers of lymphocytes, macrophoges and other mesenchymal cells. Impairment of blood flow by perisinusoidal fibrosis probably resulted in the secondary alterations in hepatocytes which included cellular atrophy and formation of cytoplasmic bullae.

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Year:  1974        PMID： 4416771      PMCID： PMC1910880     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  36 in total

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  22 in total

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Journal:  Am J Dig Dis       Date:  1977-08

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Journal:  Am J Pathol       Date:  1982-02       Impact factor: 4.307

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Journal:  Virchows Arch       Date:  2014-02-26       Impact factor: 4.064

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10.  Ultrastructural lesions of the liver in human peliosis. A report of 12 cases.

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