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Literature DB >> 10684308

Superantigen expression is driven by both mouse mammary tumor virus long terminal repeat-associated promoters in transgenic mice.

B Salmons¹, T Miethke, S Wintersperger, M Müller, G Brem, W H Günzburg.

Abstract

In addition to the usual retroviral promoter, the mouse mammary tumor virus (MMTV) long terminal repeat carries a second promoter located in the U3 region. Here we show that both of these promoters are independently able to give rise to superantigen activity in transgenic mice. The ability of multiple MMTV promoters to drive superantigen expression underscores its importance in the virus life cycle.

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Year: 2000 PMID： 10684308 PMCID： PMC111782 DOI： 10.1128/jvi.74.6.2900-2902.2000

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

17 in total

Review 1. Current perspectives in the biology of mouse mammary tumour virus.

Authors: B Salmons; W H Günzburg
Journal: Virus Res Date: 1987-08 Impact factor: 3.303

2. On the generation of diversity in endogenous superantigens.

Authors: B Salmons; S Wintersperger; W H Günzburg
Journal: Immunol Today Date: 1994-04

3. Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat.

Authors: W H Günzburg; F Heinemann; S Wintersperger; T Miethke; H Wagner; V Erfle; B Salmons
Journal: Nature Date: 1993-07-08 Impact factor: 49.962

4. Negative-acting factor and superantigen are separable activities of the mouse mammary tumor virus long terminal repeat.

Authors: S Wintersperger; B Salmons; T Miethke; V Erfle; H Wagner; W H Günzburg
Journal: Proc Natl Acad Sci U S A Date: 1995-03-28 Impact factor: 11.205

5. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

Authors: T V Golovkina; A B Jaffe; S R Ross
Journal: J Virol Date: 1994-08 Impact factor: 5.103

Review 3. The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV).

Authors: Generoso Bevilacqua
Journal: Viruses Date: 2022-08-01 Impact factor: 5.818

3 in total

Superantigen expression is driven by both mouse mammary tumor virus long terminal repeat-associated promoters in transgenic mice.

Review 1. Current perspectives in the biology of mouse mammary tumour virus.

2. On the generation of diversity in endogenous superantigens.

3. Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat.

4. Negative-acting factor and superantigen are separable activities of the mouse mammary tumor virus long terminal repeat.

5. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

6. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

7. Mouse mammary tumor virus superantigen expression in B cells is regulated by a central enhancer within the pol gene.

8. An activation-dependent, T-lymphocyte-specific transcriptional activator in the mouse mammary tumor virus env gene.

9. Production of mouse mammary tumor virus upon transfection of a recombinant proviral DNA into cultured cells.

10. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection.

1. Promoter complex in the central part of the mouse mammary tumor virus long terminal repeat.

Review 2. The Role of APOBECs in Viral Replication.

Review 3. The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV).