Literature DB >> 10681361

Streptococcus gordonii strains resistant to fluorodeoxyuridine contain mutations in the thymidine kinase gene and are deficient in thymidine kinase activity.

C A Franke1, T M Bolman, S A Ottum, K F Jones, D E Hruby.   

Abstract

Mutants of Streptococcus gordonii resistant to 5-fluorodeoxyuridine (FUdR(r)) were isolated. Each strain contained a point mutation resulting in the premature termination of the thymidine kinase (TK) open reading frame (tdk). In vitro translation of the mutant tdk coding regions resulted in synthesis of truncated TK polypeptides deficient in TK activity.

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Year:  2000        PMID： 10681361      PMCID： PMC89769          DOI： 10.1128/AAC.44.3.787-789.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

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Journal:  J Virol       Date:  1982-08       Impact factor: 5.103

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Authors:  M E Black; D E Hruby
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9.  Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.

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  9 in total
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