OBJECTIVE: To study effects of closed head injury (CHI) severity on development of corpus callosum (CC) in children, using MRI. BACKGROUND: Vulnerability of CC to diffuse axonal injury has been shown in adults and children by neuropathologic and MRI studies. Given continued development of CC through the second decade, serial MRI could characterize effects of CHI on CC growth in children. METHOD: MRI performed at 3 and 36 months after severe (mean age = 10.3 years, n = 25) and mild to moderate (mean age = 9.7 years, n = 28) CHI. Mild to moderate and severe CHI groups did not differ in demographic features. Morphometry of T1-weighted midsagittal CC by two operators with satisfactory interrater reliability yielded uncorrected and corrected CC volume. RESULTS: An interaction of occasion with CHI severity was present as CC area decreased from 3 to 36 months in severely injured children and increased in the mild to moderate CHI group. Uncorrected CC area was correlated with acute CHI severity and functional outcome at 36 months postinjury. CONCLUSIONS: Morphometric measurement of CC area provides a useful index of diffuse injury, which is related to functional outcome of CHI in children.
OBJECTIVE: To study effects of closed head injury (CHI) severity on development of corpus callosum (CC) in children, using MRI. BACKGROUND: Vulnerability of CC to diffuse axonal injury has been shown in adults and children by neuropathologic and MRI studies. Given continued development of CC through the second decade, serial MRI could characterize effects of CHI on CC growth in children. METHOD: MRI performed at 3 and 36 months after severe (mean age = 10.3 years, n = 25) and mild to moderate (mean age = 9.7 years, n = 28) CHI. Mild to moderate and severe CHI groups did not differ in demographic features. Morphometry of T1-weighted midsagittal CC by two operators with satisfactory interrater reliability yielded uncorrected and corrected CC volume. RESULTS: An interaction of occasion with CHI severity was present as CC area decreased from 3 to 36 months in severely injured children and increased in the mild to moderate CHI group. Uncorrected CC area was correlated with acute CHI severity and functional outcome at 36 months postinjury. CONCLUSIONS: Morphometric measurement of CC area provides a useful index of diffuse injury, which is related to functional outcome of CHI in children.
Authors: Julie M Stamm; Inga K Koerte; Marc Muehlmann; Ofer Pasternak; Alexandra P Bourlas; Christine M Baugh; Michelle Y Giwerc; Anni Zhu; Michael J Coleman; Sylvain Bouix; Nathan G Fritts; Brett M Martin; Christine Chaisson; Michael D McClean; Alexander P Lin; Robert C Cantu; Yorghos Tripodis; Robert A Stern; Martha E Shenton Journal: J Neurotrauma Date: 2015-09-23 Impact factor: 5.269
Authors: Yueqiao Xu; David L McArthur; Jeffry R Alger; Maria Etchepare; David A Hovda; Thomas C Glenn; Sungcheng Huang; Ivo Dinov; Paul M Vespa Journal: J Cereb Blood Flow Metab Date: 2009-12-23 Impact factor: 6.200
Authors: Amery Treble; Khader M Hasan; Amal Iftikhar; Karla K Stuebing; Larry A Kramer; Charles S Cox; Paul R Swank; Linda Ewing-Cobbs Journal: J Neurotrauma Date: 2013-08-24 Impact factor: 5.269
Authors: Talin Babikian; Sarah Deboard Marion; Sarah Copeland; Jeffry R Alger; Joseph O'Neill; Fabienne Cazalis; Richard Mink; Christopher C Giza; Jennifer A Vu; Suzanne M Hilleary; Claudia L Kernan; Nina Newman; Robert F Asarnow Journal: J Neurotrauma Date: 2010-03 Impact factor: 5.269