Literature DB >> 10679890

Are there two distinct research strategies for developing biologically active molecules: rational design and empirical selection?

M H Van Regenmortel.   

Abstract

Mesh：

Year:  2000        PMID： 10679890     DOI： 10.1002/(SICI)1099-1352(200001/02)13:1<1::AID-JMR490>3.0.CO;2-W

Source DB:  PubMed          Journal:  J Mol Recognit        ISSN： 0952-3499            Impact factor:   2.137


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  4 in total

1.  Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism.

Authors:  Marc H V Van Regenmortel
Journal:  EMBO Rep       Date:  2004-11       Impact factor: 8.807

2.  VeloceGenomics: an accelerated in vivo drug discovery approach to rapidly predict the biologic, drug-like activity of compounds, proteins, or genes.

Authors:  Ruben Papoian; Andreas Scherer; Muriel Saulnier; Frank Staedtler; André Cordier; Francois Legay; Gerard Maurer; Joerg Staeheli; Jacky Vonderscher; Salah-Dine Chibout
Journal:  Pharm Res       Date:  2005-09-22       Impact factor: 4.200

3.  Exploiting models of molecular evolution to efficiently direct protein engineering.

Authors:  Megan F Cole; Eric A Gaucher
Journal:  J Mol Evol       Date:  2010-12-04       Impact factor: 2.395

4.  Engineering proteinase K using machine learning and synthetic genes.

Authors:  Jun Liao; Manfred K Warmuth; Sridhar Govindarajan; Jon E Ness; Rebecca P Wang; Claes Gustafsson; Jeremy Minshull
Journal:  BMC Biotechnol       Date:  2007-03-26       Impact factor: 2.563
  4 in total

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