Literature DB >> 10679384

RecQ family helicases: roles in cancer and aging.

J K Karow1, L Wu, I D Hickson.   

Abstract

The RecQ family of DNA helicases includes at least three members in humans that are defective in genetic disorders associated with cancer predisposition and/or premature aging. Recent studies have shed light on the roles of RecQ helicases in suppressing 'promiscuous' genetic recombination and in ensuring accurate chromosome segregation. In particular, the biochemical properties of several family members have been characterised and functional interactions with other nuclear proteins have been defined.

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Year:  2000        PMID： 10679384     DOI： 10.1016/s0959-437x(99)00039-8

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  59 in total

1.  The Bloom's syndrome gene product promotes branch migration of holliday junctions.

Authors:  J K Karow; A Constantinou; J L Li; S C West; I D Hickson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

2.  Molecular characterisation of RecQ homologues in Arabidopsis thaliana.

Authors:  F Hartung; H Plchová; H Puchta
Journal:  Nucleic Acids Res       Date:  2000-11-01       Impact factor: 16.971

3.  The Aspergillus nidulans musN gene encodes a RecQ helicase that interacts with the PI-3K-related kinase UVSB.

Authors:  A F Hofmann; S D Harris
Journal:  Genetics       Date:  2001-12       Impact factor: 4.562

Review 4.  Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination.

Authors:  J Courcelle; P C Hanawalt
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

5.  Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.

Authors:  R Freire; F d'Adda Di Fagagna; L Wu; G Pedrazzi; I Stagljar; I D Hickson; S P Jackson
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

6.  Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells.

Authors:  S Tada; T Kobayashi; A Omori; Y Kusa; N Okumura; H Kodaira; Y Ishimi; M Seki; T Enomoto
Journal:  Nucleic Acids Res       Date:  2001-09-15       Impact factor: 16.971

7.  The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

Authors:  P Mohaghegh; J K Karow; R M Brosh; V A Bohr; I D Hickson
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

8.  Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

Authors:  P Pichierri; A Franchitto; P Mosesso; F Palitti
Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

9.  Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIbeta.

Authors:  Tina Wilson-Sali; Tao-Shih Hsieh
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

10.  The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.

Authors:  Leonard Wu; Ian D Hickson
Journal:  Nucleic Acids Res       Date:  2002-11-15       Impact factor: 16.971
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