OBJECTIVE: To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry. INTERVENTIONS: Implantation of phosphorylcholine coated (n = 20) and non-coated (n = 21) stents was performed in the coronary arteries of 25 pigs. The animals were killed after five days (n = 6), four weeks (n = 7), and 12 weeks (n = 8), and the vessels harvested for histology, scanning electron microscopy, and morphometry. MAIN OUTCOME MEASURES: Stent performance was assessed by studying early endothelialization, neointima formation, and vessel wall reaction to the synthetic coating. RESULTS: Stent thrombosis did not occur in either group. Morphometry showed no significant differences between the two study groups at any time point. At five days both the coated and non-coated stents were equally well endothelialised (91% v 92%, respectively). At four and 12 weeks there was no difference in intimal thickness between the coated and non-coated stents. Up to 12 weeks postimplant the phosphorylcholine coating was still discernible in the stent strut voids, and did not appear to elicit an adverse inflammatory response. CONCLUSION: In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting. Given that the coating was present up to 12 weeks postimplant with no adverse tissue reaction, it may be a potential candidate polymer for local drug delivery.
OBJECTIVE: To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry. INTERVENTIONS: Implantation of phosphorylcholine coated (n = 20) and non-coated (n = 21) stents was performed in the coronary arteries of 25 pigs. The animals were killed after five days (n = 6), four weeks (n = 7), and 12 weeks (n = 8), and the vessels harvested for histology, scanning electron microscopy, and morphometry. MAIN OUTCOME MEASURES: Stent performance was assessed by studying early endothelialization, neointima formation, and vessel wall reaction to the synthetic coating. RESULTS: Stent thrombosis did not occur in either group. Morphometry showed no significant differences between the two study groups at any time point. At five days both the coated and non-coated stents were equally well endothelialised (91% v 92%, respectively). At four and 12 weeks there was no difference in intimal thickness between the coated and non-coated stents. Up to 12 weeks postimplant the phosphorylcholine coating was still discernible in the stent strut voids, and did not appear to elicit an adverse inflammatory response. CONCLUSION: In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting. Given that the coating was present up to 12 weeks postimplant with no adverse tissue reaction, it may be a potential candidate polymer for local drug delivery.
Authors: I K De Scheerder; K L Wilczek; E V Verbeken; J Vandorpe; P N Lan; E Schacht; J Piessens; H De Geest Journal: Cardiovasc Intervent Radiol Date: 1995 Jul-Aug Impact factor: 2.740
Authors: D Keane; J Haase; C J Slager; E Montauban van Swijndregt; K G Lehmann; Y Ozaki; C di Mario; R Kirkeeide; P W Serruys Journal: Circulation Date: 1995-04-15 Impact factor: 29.690
Authors: I K De Scheerder; K L Wilczek; E V Verbeken; J Vandorpe; P N Lan; E Schacht; H De Geest; J Piessens Journal: Atherosclerosis Date: 1995-04-07 Impact factor: 5.162
Authors: P A Hårdhammar; H M van Beusekom; H U Emanuelsson; S H Hofma; P A Albertsson; P D Verdouw; E Boersma; P W Serruys; W J van der Giessen Journal: Circulation Date: 1996-02-01 Impact factor: 29.690
Authors: C M Goods; K F Al-Shaibi; S S Yadav; M W Liu; B H Negus; S S Iyer; L S Dean; S P Jain; W A Baxley; J M Parks; R J Sutor; G S Roubin Journal: Circulation Date: 1996-05-15 Impact factor: 29.690
Authors: Jessica Amber Jennings; Daniel P Carpenter; Karen S Troxel; Karen E Beenken; Mark S Smeltzer; Harry S Courtney; Warren O Haggard Journal: Clin Orthop Relat Res Date: 2015-07 Impact factor: 4.176