Literature DB >> 10675527

First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis.

W Jarmuszkiewicz1, G Milani, F Fortes, A Z Schreiber, F E Sluse, A E Vercesi.   

Abstract

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant UCP. Activity of CpUCP, investigated in mitochondria depleted of free fatty acids, was stimulated by linoleic acid (LA) and inhibited by GTP. Activity of CpUCP enhanced state 4 respiration by decreasing DeltaPsi and lowered the ADP/O ratio. Thus, it was able to divert energy from oxidative phosphorylation. The voltage dependence of electron flux indicated that LA had a pure protonophoretic effect. The discovery of CpUCP proves that UCP-like proteins occur in the four eukaryotic kingdoms: animals, plants, fungi and protists.

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Year:  2000        PMID： 10675527     DOI： 10.1016/s0014-5793(00)01138-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

Review 1.  Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.

Authors:  Vicente de Paulo Martins; Taisa Magnani Dinamarco; Carlos Curti; Sérgio Akira Uyemura
Journal:  J Bioenerg Biomembr       Date:  2011-02       Impact factor: 2.945

2.  Involvement of Drosophila uncoupling protein 5 in metabolism and aging.

Authors:  Adolfo Sánchez-Blanco; Yih-Woei C Fridell; Stephen L Helfand
Journal:  Genetics       Date:  2005-12-30       Impact factor: 4.562

3.  Identification and characterization of uncoupling protein in heart and muscle mitochondria of canary birds.

Authors:  Malgorzata B Slocinska; Zakaria Ali Moh Almsherqi; Francis E Sluse; Rachel Navet; Yuru Deng
Journal:  J Bioenerg Biomembr       Date:  2010-08-05       Impact factor: 2.945

4.  Inhibition of specific electron transport pathways leads to oxidative stress and decreased Candida albicans proliferation.

Authors:  Fernando Ruy; Anibal E Vercesi; Alicia J Kowaltowski
Journal:  J Bioenerg Biomembr       Date:  2006-10-12       Impact factor: 2.945

5.  In phosphorylating Acanthamoeba castellanii mitochondria the sensitivity of uncoupling protein activity to GTP depends on the redox state of quinone.

Authors:  Wieslawa Jarmuszkiewicz; Aleksandra Swida; Malgorzata Czarna; Nina Antos; Claudine M Sluse-Goffart; Francis E Sluse
Journal:  J Bioenerg Biomembr       Date:  2005-04       Impact factor: 2.945

Review 6.  Biology and genetics of the pathogenic yeast Candida parapsilosis.

Authors:  Jozef Nosek; Zuzana Holesova; Peter Kosa; Attila Gacser; Lubomir Tomaska
Journal:  Curr Genet       Date:  2009-08-07       Impact factor: 3.886

7.  The expression of alternative oxidase and uncoupling protein during fruit ripening in mango.

Authors:  M J Considine; D O Daley; J Whelan
Journal:  Plant Physiol       Date:  2001-08       Impact factor: 8.340

8.  Functional characterization of a Drosophila mitochondrial uncoupling protein.

Authors:  Yih-Woei C Fridell; Adolfo Sánchez-Blanco; Brian A Silvia; Stephen L Helfand
Journal:  J Bioenerg Biomembr       Date:  2004-06       Impact factor: 2.945

9.  Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence.

Authors:  Adrienne Bambach; Mariana P Fernandes; Anup Ghosh; Michael Kruppa; Deepu Alex; Dongmei Li; William A Fonzi; Neeraj Chauhan; Nuo Sun; Orlando A Agrellos; Anibal E Vercesi; Ronda J Rolfes; Richard Calderone
Journal:  Eukaryot Cell       Date:  2009-08-28

10.  Functional characterization of an uncoupling protein in goldfish white skeletal muscle.

Authors:  Reinaldo Sousa dos Santos; Flavia Letícia Martins Peçanha; Wagner Seixas da-Silva
Journal:  J Bioenerg Biomembr       Date:  2013-04-23       Impact factor: 2.945
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