Literature DB >> 20686918

Identification and characterization of uncoupling protein in heart and muscle mitochondria of canary birds.

Malgorzata B Slocinska1, Zakaria Ali Moh Almsherqi, Francis E Sluse, Rachel Navet, Yuru Deng.   

Abstract

An uncoupling protein (cUCP) was identified in heart and skeletal muscle mitochondria of canary birds. cUCP was immunodetected using polyclonal antibodies raised against murine UCP2. Its molecular mass was similar to those of mammalian UCPs (32 kDa). The activity of cUCP was stimulated by palmitic acid (PA) and inhibited by GTP mainly in state 3 respiration. Additions of PA augmented state 4 respiration and lowered the ADP/O ratio. Thus, the activity of cUCP diverted energy from oxidative phosphorylation in state 3 respiration. cUCP in heart and skeletal muscles of canary birds might have implications in thermogenesis as well as protection against free radical production.

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Year:  2010        PMID： 20686918     DOI： 10.1007/s10863-010-9303-x

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  52 in total

Review 1.  Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants.

Authors:  V P Skulachev
Journal:  Q Rev Biophys       Date:  1996-05       Impact factor: 5.318

2.  Electron partitioning between the two branching quinol-oxidizing pathways in Acanthamoeba castellanii mitochondria during steady-state state 3 respiration.

Authors:  W Jarmuszkiewicz; C M Sluse-Goffart; L Hryniewiecka; J Michejda; F E Sluse
Journal:  J Biol Chem       Date:  1998-04-24       Impact factor: 5.157

Review 3.  The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.

Authors:  D Ricquier; F Bouillaud
Journal:  Biochem J       Date:  2000-01-15       Impact factor: 3.857

4.  The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells.

Authors:  D P Maxwell; Y Wang; L McIntosh
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 5.  The biochemistry of an inefficient tissue: brown adipose tissue.

Authors:  B Cannon; J Nedergaard
Journal:  Essays Biochem       Date:  1985       Impact factor: 8.000

Review 6.  Thermogenic mechanisms in brown fat.

Authors:  D G Nicholls; R M Locke
Journal:  Physiol Rev       Date:  1984-01       Impact factor: 37.312

7.  Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii.

Authors:  W Jarmuszkiewicz; C M Sluse-Goffart; L Hryniewiecka; F E Sluse
Journal:  J Biol Chem       Date:  1999-08-13       Impact factor: 5.157

8.  Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.

Authors:  C Fleury; M Neverova; S Collins; S Raimbault; O Champigny; C Levi-Meyrueis; F Bouillaud; M F Seldin; R S Surwit; D Ricquier; C H Warden
Journal:  Nat Genet       Date:  1997-03       Impact factor: 38.330

9.  Superoxide activates mitochondrial uncoupling proteins.

Authors:  Karim S Echtay; Damien Roussel; Julie St-Pierre; Mika B Jekabsons; Susana Cadenas; Jeff A Stuart; James A Harper; Stephen J Roebuck; Alastair Morrison; Susan Pickering; John C Clapham; Martin D Brand
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

Review 10.  Uncoupling protein 3 biological activity.

Authors:  J P Giacobino
Journal:  Biochem Soc Trans       Date:  2001-11       Impact factor: 5.407
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  1 in total

1.  Functional characterization of an uncoupling protein in goldfish white skeletal muscle.

Authors:  Reinaldo Sousa dos Santos; Flavia Letícia Martins Peçanha; Wagner Seixas da-Silva
Journal:  J Bioenerg Biomembr       Date:  2013-04-23       Impact factor: 2.945
  1 in total

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