Literature DB >> 10673093

Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity.

S S Jew1, C H Yoo, D Y Lim, H Kim, I Mook-Jung, M W Jung, H Choi, Y H Jung, H Kim, H G Park.   

Abstract

8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.

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Year:  2000        PMID： 10673093     DOI： 10.1016/s0960-894x(99)00658-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Effect of asiatic acid on the Ang II-AT1R-NADPH oxidase-NF-κB pathway in renovascular hypertensive rats.

Authors:  Putcharawipa Maneesai; Sarawoot Bunbupha; Upa Kukongviriyapan; Laddawan Senggunprai; Veerapol Kukongviriyapan; Parichat Prachaney; Poungrat Pakdeechote
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-07-21       Impact factor: 3.000

2.  Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.

Authors:  Min-fang Xu; Yu-yun Xiong; Jian-kang Liu; Jin-jun Qian; Li Zhu; Jing Gao
Journal:  Acta Pharmacol Sin       Date:  2012-03-26       Impact factor: 6.150

Review 3.  Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise.

Authors:  Mohamed Fizur Nagoor Meeran; Sameer N Goyal; Kapil Suchal; Charu Sharma; Chandragouda R Patil; Shreesh K Ojha
Journal:  Front Pharmacol       Date:  2018-09-04       Impact factor: 5.810

4.  Centella asiatica - Phytochemistry and mechanisms of neuroprotection and cognitive enhancement.

Authors:  Nora E Gray; Armando Alcazar Magana; Parnian Lak; Kirsten M Wright; Joseph Quinn; Jan F Stevens; Claudia S Maier; Amala Soumyanath
Journal:  Phytochem Rev       Date:  2017-09-20       Impact factor: 5.374

5.  Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.

Authors:  Amala Soumyanath; Yong-Ping Zhong; Edward Henson; Teri Wadsworth; James Bishop; Bruce G Gold; Joseph F Quinn
Journal:  Int J Alzheimers Dis       Date:  2012-02-15

6.  The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC).

Authors:  Faridah Hussin; Sima Ataollahi Eshkoor; Asmah Rahmat; Fauziah Othman; Abdah Akim
Journal:  BMC Complement Altern Med       Date:  2014-01-20       Impact factor: 3.659

7.  Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo.

Authors:  Yue Jing; Gang Wang; Qi Xiao; Yachun Zhou; Yingjie Wei; Zhunan Gong
Journal:  Onco Targets Ther       Date:  2018-04-04       Impact factor: 4.147

8.  Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia.

Authors:  Rajanikant G Krishnamurthy; Marie-Claude Senut; Daniel Zemke; Jiangyong Min; Mark B Frenkel; Eric J Greenberg; Seong-Woon Yu; Nick Ahn; John Goudreau; Mounzer Kassab; Kiran S Panickar; Arshad Majid
Journal:  J Neurosci Res       Date:  2009-08-15       Impact factor: 4.164

9.  Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma.

Authors:  Wanjing Huang; Fengjuan Gao; Fangyuan Hu; Jiancheng Huang; Min Wang; Ping Xu; Rong Zhang; Junyi Chen; Xinghuai Sun; Shenghai Zhang; Jihong Wu
Journal:  Front Neurosci       Date:  2018-07-20       Impact factor: 4.677

10.  Weed Suppressing Potential and Isolation of Potent Plant Growth Inhibitors from Castanea crenata Sieb. et Zucc.

Authors:  Phung Thi Tuyen; Tran Dang Xuan; Truong Thi Tu Anh; Truong Mai Van; Ateeque Ahmad; Abdelnaser Abdelghany Elzaawely; Tran Dang Khanh
Journal:  Molecules       Date:  2018-02-07       Impact factor: 4.411
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