Literature DB >> 10673088

Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety.

Y K Kang1, K J Shin, K H Yoo, K J Seo, C Y Hong, C S Lee, S Y Park, D J Kim, S W Park.   

Abstract

The synthesis and biological activity of a series of new 1beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.

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Year:  2000        PMID： 10673088     DOI： 10.1016/s0960-894x(99)00646-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  An experimental and theoretical structural study of 5-amino-3-methylisoxazolo-4-carboxylic acid p-chlorophenylamide.

Authors:  Aneta Jezierska; Jarosław Panek; Stanisław Ryng; Tadeusz Głowiak; Aleksander Koll
Journal:  J Mol Model       Date:  2003-04-05       Impact factor: 1.810

2.  Mechanistic Pathways in Amide Activation: Flexible Synthesis of Oxazoles and Imidazoles.

Authors:  Giovanni Di Mauro; Boris Maryasin; Daniel Kaiser; Saad Shaaban; Leticia González; Nuno Maulide
Journal:  Org Lett       Date:  2017-07-13       Impact factor: 6.005

3.  (5S,6S,10R)-10-(2,4-Dichloro-phen-yl)-14-[(E)-(2,4-dichloro-phen-yl)methyl-idene]-3,9-diphenyl-12-[(R)-1-phenyl-ethyl]-1,4,7-trioxa-2,8,12-triaza-dispiro-[4.0.4.4]tetra-deca-2,8-diene.

Authors:  S Mahalakshmi; R Suresh Kumar; S Perumal; V Sivakumar; J Suresh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

4.  2-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]phenol.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Abdullah M Asiri; Salman A Khan; Khalid A Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-06

5.  5-Methyl-3-[1-(2-pyridylmeth-yl)-1H-benzimidazol-2-ylmeth-yl]isoxazole.

Authors:  Mohamadou Lamine Doumbia; Rachid Bouhfid; El Mokhtar Essassi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-10

6.  5-Methyl-3-phenyl-isoxazole-4-carb-oxy-lic acid.

Authors:  N Srikantamurthy; G J Vishalakshi; S Jeyaseelan; K B Umesha; M Mahendra
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-15

7.  Bis[N-cyclohexyl-1-(2-{1-[(cyclohexyl-amino)carbonyl]cyclohexyl}-3,5-dioxo-1,2-oxazolidin-4-yl)cyclopentanecarbox-amide] monohydrate.

Authors:  Enayatollah Sheikhhosseini; Fahime Vafadarnejad; Azizollah Habibi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-02

8.  Cu/TCH-pr@SBA-15 nano-composite: a new organometallic catalyst for facile three-component synthesis of 4-arylidene-isoxazolidinones.

Authors:  Mehdi Kalhor; Seyed Mehdi Sajjadi; Akbar Dadras
Journal:  RSC Adv       Date:  2020-07-22       Impact factor: 3.361

9.  (Z)-4-Benzyl-idene-3-methyl-isoxazol-5(4H)-one.

Authors:  N Srikantamurthy; S Jeyaseelan; K B Umesha; K Palani; M Mahendra
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-10-10

10.  Synthesis of Some New 3, 5-Bis (substituted) Pyrazoles and Isoxazoles Based on (N'(1)E, N'(3)E)- N'(1), N'(3)-Bis (3, 4, 5-substitutedbenzlidene) Malonohydrazide under Solvothermal Conditions.

Authors:  Ebraheem Abdu Musad; Kuriya Madavu Lokanatha Rai; Kullaiah Byrappa
Journal:  Int J Biomed Sci       Date:  2010-03
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