Literature DB >> 10667368

12-Lipoxygenase products increase monocyte:endothelial interactions.

C C Hedrick1, M D Kim, R D Natarajan, J L Nadler.   

Abstract

In summary, we suggest that hyperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.

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Year:  1999        PMID： 10667368     DOI： 10.1007/978-1-4615-4793-8_67

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  9 in total

1.  p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice.

Authors:  P A Barry-Lane; C Patterson; M van der Merwe; Z Hu; S M Holland; E T Yeh; M S Runge
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

Review 2.  Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes.

Authors:  Milagros G Huerta; Jerry L Nadler
Journal:  Curr Diab Rep       Date:  2002-10       Impact factor: 4.810

3.  Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.

Authors:  Jan Rossaint; Jerry L Nadler; Klaus Ley; Alexander Zarbock
Journal:  Crit Care       Date:  2012-09-13       Impact factor: 9.097

4.  Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Authors:  Ganesha Rai; Netra Joshi; Joo Eun Jung; Yu Liu; Lena Schultz; Adam Yasgar; Steve Perry; Giovanni Diaz; Qiangli Zhang; Victor Kenyon; Ajit Jadhav; Anton Simeonov; Eng H Lo; Klaus van Leyen; David J Maloney; Theodore R Holman
Journal:  J Med Chem       Date:  2014-05-13       Impact factor: 7.446

5.  Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction.

Authors:  Yong Wang; Weili Lin; Chun Li; Sarita Singhal; Gaurav Jain; Lixin Zhu; Linghui Lu; Ruixin Zhu; Wei Wang
Journal:  Front Pharmacol       Date:  2017-03-02       Impact factor: 5.810

6.  Modulation of proinflammatory cytokines and enzymes by polyherbal formulation Guggulutiktaka ghritam.

Authors:  Mohind C Mohan; Anu P Abhimannue; B Prakash Kumar
Journal:  J Ayurveda Integr Med       Date:  2019-01-11

7.  Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.

Authors:  Lisa U Magnusson; Annika Lundqvist; Merja Nurkkala Karlsson; Kristina Skålén; Max Levin; Olov Wiklund; Jan Borén; Lillemor Mattsson Hultén
Journal:  PLoS One       Date:  2012-08-17       Impact factor: 3.240

8.  Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol.

Authors:  Daniëlle M P H J Boesten; Alvin Berger; Peter de Cock; Hua Dong; Bruce D Hammock; Gertjan J M den Hartog; Aalt Bast
Journal:  PLoS One       Date:  2013-06-05       Impact factor: 3.240

9.  12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.

Authors:  Xiaofang Wang; Lu Gao; Lili Xiao; Lulu Yang; Wenshu Li; Gangqiong Liu; Linlin Chen; Jinying Zhang
Journal:  J Diabetes Investig       Date:  2018-10-24       Impact factor: 4.232
  9 in total

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