Literature DB >> 12643164

Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes.

Milagros G Huerta1, Jerry L Nadler.   

Abstract

Experimental and epidemiologic studies support the role of inflammation in the development of type 2 diabetes and atherosclerosis. Serum levels of inflammatory markers, in particular highly sensitive C-reactive protein, have been found to be strong predictors of increased risk for type 2 diabetes and cardiovascular disease independent of traditional risk factors. A beneficial effect of thiazolidinediones, angiotensin-converting enzyme inhibitors, and statins in the prevention of type 2 diabetes and cardiovascular events has recently been reported, and potential anti-inflammatory mechanisms of action for these compounds have been described. Prospective, randomized clinical trials are currently underway to confirm these initial findings and define indications for treatment of patients at risk.

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Year:  2002        PMID： 12643164     DOI： 10.1007/s11892-002-0103-5

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  51 in total

1.  Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study.

Authors:  M A Albert; E Danielson; N Rifai; P M Ridker
Journal:  JAMA       Date:  2001-07-04       Impact factor: 56.272

2.  Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.

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Journal:  J Clin Endocrinol Metab       Date:  2000-09       Impact factor: 5.958

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Authors:  R Natarajan; R G Gerrity; J-L Gu; L Lanting; L Thomas; J L Nadler
Journal:  Diabetologia       Date:  2002-01       Impact factor: 10.122

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Journal:  Lancet       Date:  1999-05-15       Impact factor: 79.321

5.  The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus.

Authors:  S Rosenblatt; B Miskin; N B Glazer; M J Prince; K E Robertson
Journal:  Coron Artery Dis       Date:  2001-08       Impact factor: 1.439

6.  Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

Authors:  A Festa; R D'Agostino; G Howard; L Mykkänen; R P Tracy; S M Haffner
Journal:  Circulation       Date:  2000-07-04       Impact factor: 29.690

7.  Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.

Authors:  Lars H Lindholm; Hans Ibsen; Björn Dahlöf; Richard B Devereux; Gareth Beevers; Ulf de Faire; Frej Fyhrquist; Stevo Julius; Sverre E Kjeldsen; Krister Kristiansson; Ole Lederballe-Pedersen; Markku S Nieminen; Per Omvik; Suzanne Oparil; Hans Wedel; Peter Aurup; Jonathan Edelman; Steven Snapinn
Journal:  Lancet       Date:  2002-03-23       Impact factor: 79.321

Review 8.  Diabetes and cardiovascular disease. The "common soil" hypothesis.

Authors:  M P Stern
Journal:  Diabetes       Date:  1995-04       Impact factor: 9.461

9.  Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.

Authors:  J R Downs; M Clearfield; S Weis; E Whitney; D R Shapiro; P A Beere; A Langendorfer; E A Stein; W Kruyer; A M Gotto
Journal:  JAMA       Date:  1998-05-27       Impact factor: 56.272

10.  Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group.

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Journal:  N Engl J Med       Date:  1995-11-16       Impact factor: 91.245
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  2 in total

1.  LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes.

Authors:  Biao Lu; Yang Lu; Arthur H Moser; Judy K Shigenaga; Carl Grunfeld; Kenneth R Feingold
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-10-21       Impact factor: 4.310

2.  A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.

Authors:  Tommy Jönsson; Bo Ahrén; Giovanni Pacini; Frank Sundler; Nils Wierup; Stig Steen; Trygve Sjöberg; Martin Ugander; Johan Frostegård; Leif Göransson; Staffan Lindeberg
Journal:  Nutr Metab (Lond)       Date:  2006-11-02       Impact factor: 4.169
  2 in total

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