Literature DB >> 10652290

Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices.

H Rosenfeldt1, F Grinnell.   

Abstract

Fibroblasts in mechanically unloaded collagen matrices had low levels of DNA synthesis compared with cells in mechanically loaded matrices. Under the former conditions, the cellular ERK signaling pathway appeared to be disrupted. Also, pharmacologic inhibition of ERK signaling blocked DNA synthesis by fibroblasts in mechanically loaded matrices. These results were consistent with the idea that mechanoregulation of fibroblast DNA synthesis in collagen matrices occurs at the level of the ERK signaling pathway.

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Year:  2000        PMID： 10652290     DOI： 10.1074/jbc.275.5.3088

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  23 in total

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