BACKGROUND: The soluble intercellular adhesion molecule-1 (sICAM-1) is a marker for the activation of the cellular immune system. Since an activation of the immune system has been observed in a part of the schizophrenic patients, we measured the serum levels of soluble ICAM-1 (sICAM-1) in schizophrenic patients and correlated them to the patient's psychopathology. METHODS: To monitor a possible effect of antipsychotic therapy, 36 schizophrenic patients were examined twice: first without antipsychotic medication immediately after admission to the hospital and then, after clinical improvement before discharge. The results were compared with those of 36 age- and gender-related healthy individuals. RESULTS: The schizophrenic patients showed significantly decreased serum levels of sICAM-1 at the first examination (248 +/- 95 ng/mL) and at re-examination (266 +/- 95 ng/mL) compared with the comparison group (323 +/- 74 ng/mL). Patients with more pronounced negative symptoms showed higher levels of sICAM-1 at the first examination. CONCLUSIONS: We conclude that reduced sICAM-1 levels in schizophrenia indicate a reduced activity of the cellular immune system in at least a subgroup of schizophrenic patients.
BACKGROUND: The soluble intercellular adhesion molecule-1 (sICAM-1) is a marker for the activation of the cellular immune system. Since an activation of the immune system has been observed in a part of the schizophrenicpatients, we measured the serum levels of soluble ICAM-1 (sICAM-1) in schizophrenicpatients and correlated them to the patient's psychopathology. METHODS: To monitor a possible effect of antipsychotic therapy, 36 schizophrenicpatients were examined twice: first without antipsychotic medication immediately after admission to the hospital and then, after clinical improvement before discharge. The results were compared with those of 36 age- and gender-related healthy individuals. RESULTS: The schizophrenicpatients showed significantly decreased serum levels of sICAM-1 at the first examination (248 +/- 95 ng/mL) and at re-examination (266 +/- 95 ng/mL) compared with the comparison group (323 +/- 74 ng/mL). Patients with more pronounced negative symptoms showed higher levels of sICAM-1 at the first examination. CONCLUSIONS: We conclude that reduced sICAM-1 levels in schizophrenia indicate a reduced activity of the cellular immune system in at least a subgroup of schizophrenicpatients.
Authors: Tanya T Nguyen; Sheena I Dev; Guanqing Chen; Sharon C Liou; Averria Sirkin Martin; Michael R Irwin; Judith E Carroll; Xin Tu; Dilip V Jeste; Lisa T Eyler Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-09-23 Impact factor: 5.270
Authors: Giselli Scaini; Tássia Tonon; Carolina F Moura de Souza; Patricia F Schuck; Gustavo C Ferreira; João Quevedo; João Seda Neto; Tatiana Amorim; Jose S Camelo; Ana Vitoria Barban Margutti; Rafael Hencke Tresbach; Fernanda Sperb-Ludwig; Raquel Boy; Paula F V de Medeiros; Ida Vanessa D Schwartz; Emilio Luiz Streck Journal: J Inherit Metab Dis Date: 2018-05-08 Impact factor: 4.982