Literature DB >> 26160200

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls.

Marco Calabrò, Calabrò Marco1, Antonio Drago, Drago Antonio2, Antonina Sidoti, Sidoti Antonina3, Alessandro Serretti, Serretti Alessandro4, Concetta Crisafulli, Crisafulli Concetta5.   

Abstract

A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Pathway analysis; Pruning; Schizophrenia

Mesh：

Year:  2015        PMID： 26160200      PMCID： PMC4532584          DOI： 10.1016/j.psychres.2015.06.013

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  51 in total

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