BACKGROUND: There is conflicting evidence about the frequency of adverse pregnancy outcomes among women with schizophrenia. AIMS: To investigate the risk of preterm birth, low birth weight and intra-uterine growth retardation among women with schizophrenia. METHOD: A total of 2212 births to 1537 women with schizophrenia in Denmark were compared with a random sample of all deliveries in Denmark in 1973-1993 (122,931 births to 72,742 women). RESULTS: The children of women with schizophrenia were at increased risk of preterm delivery (relative risk = 1.46, 95% CI = 1.19-1.79), low birth weight (relative risk = 1.57, 95% CI = 1.36-1.82) and small for gestational age (relative risk = 1.34, 95% CI = 1.17-1.53). CONCLUSIONS: Women with schizophrenia are at increased risk of adverse pregnancy outcome. This may be associated with an increased mortality and general morbidity and risk of schizophrenia in their children.
BACKGROUND: There is conflicting evidence about the frequency of adverse pregnancy outcomes among women with schizophrenia. AIMS: To investigate the risk of preterm birth, low birth weight and intra-uterine growth retardation among women with schizophrenia. METHOD: A total of 2212 births to 1537 women with schizophrenia in Denmark were compared with a random sample of all deliveries in Denmark in 1973-1993 (122,931 births to 72,742 women). RESULTS: The children of women with schizophrenia were at increased risk of preterm delivery (relative risk = 1.46, 95% CI = 1.19-1.79), low birth weight (relative risk = 1.57, 95% CI = 1.36-1.82) and small for gestational age (relative risk = 1.34, 95% CI = 1.17-1.53). CONCLUSIONS:Women with schizophrenia are at increased risk of adverse pregnancy outcome. This may be associated with an increased mortality and general morbidity and risk of schizophrenia in their children.
Authors: Quetzal A Class; Martin E Rickert; Henrik Larsson; Paul Lichtenstein; Brian M D'Onofrio Journal: Br J Psychiatry Date: 2014-09-25 Impact factor: 9.319
Authors: Louise H Flick; Cynthia A Cook; Sharon M Homan; Maryellen McSweeney; Claudia Campbell; Lisa Parnell Journal: Am J Public Health Date: 2006-10 Impact factor: 9.308
Authors: Elina Jokiranta; Alan S Brown; Markus Heinimaa; Keely Cheslack-Postava; Auli Suominen; Andre Sourander Journal: Psychiatry Res Date: 2013-02-04 Impact factor: 3.222