| Literature DB >> 10640672 |
M Zhou1, O Tanaka, M Sekiguchi, K Sakabe, M Anzai, I Izumida, T Inoue, K Kawahara, H Abe.
Abstract
The Kir6.1/uK(ATP)-1, subunit of ATP-sensitive K(+) channels (K(ATP)), was localized in adult rat brain by in situ hybridization and immunohistochemistry. The mRNA of this subunit was ubiquitously expressed in various neurons and nuclei of the adult rat brain. Interestingly, Kir6.1/uK(ATP)-1 mRNA was also expressed in glial cells. Kir6.1/uK(ATP)-1 protein staining gave a dispersed array of fine dots throughout all neurons and glial cells examined. Under electron microscope, the immunoreactive products were specifically restricted to the mitochondria. The present study indicates that this K(ATP) subunit is localized in the mitochondria and may play a fundamental role in vital brain function.Entities:
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Year: 1999 PMID： 10640672 DOI： 10.1016/s0169-328x(99)00232-6
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X