| Literature DB >> 23291191 |
Andrew P Wojtovich1, C Owen Smith, Cole M Haynes, Keith W Nehrke, Paul S Brookes.
Abstract
In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be involved in the assembly of the mKATP. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.Entities:
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Year: 2013 PMID： 23291191 PMCID： PMC3880126 DOI： 10.1016/j.bbabio.2012.12.007
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002