| Literature DB >> 10640638 |
F Yang1, K Uéda, P Chen, K H Ashe, G M Cole.
Abstract
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of alpha-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human betaAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and alpha-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD.Entities:
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Year: 2000 PMID： 10640638 DOI： 10.1016/s0006-8993(99)02207-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252