Literature DB >> 1064045

Kinetics of glucagon in man: effects of starvation.

M Fisher, R S Sherwin, R Hendler, P Felig.   

Abstract

Serum stimulates the production of prostaglandins by transformed mouse fibroblasts. Hydrocortisone (cortisol) inhibits this stimulation. The half-maximal inhibition occurs at 6x10-9 M. Studies with cells labeled with [3H]arachidonic acid in their lipids show that the stimulation by serum results in the release of arachidonic acid from the cellular lipids, mostly phospholipids. Hydrocortisone inhibits this release but does not inhibit the production of prostaglandins from exogenously supplied arachidonic acid. This inhibition of arachidonic acid release from phospholipids may be the mechanism for the anti-inflammatory action of corticosteroids.

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Year:  1976        PMID： 1064045      PMCID： PMC430375          DOI： 10.1073/pnas.73.5.1735

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

Review 1.  REVIEW: THE USE OF ISOTOPIC STEROIDS FOR THE MEASUREMENT OF PRODUCTION RATES IN VIVO.

Authors:  J F TAIT
Journal:  J Clin Endocrinol Metab       Date:  1963-12       Impact factor: 5.958

2.  Metabolic clearance of insulin in man.

Authors:  S M Genuth
Journal:  Diabetes       Date:  1972-10       Impact factor: 9.461

3.  Abnormal pancreatic alpha-cell function in bacterial infections.

Authors:  D M Rocha; F Santeusanio; G R Faloona; R H Unger
Journal:  N Engl J Med       Date:  1973-04-05       Impact factor: 91.245

4.  Concentrations of glucagon and the insulin:glucagon ratio in the portal and peripheral circulation.

Authors:  P Felig; R Gusberg; R Hendler; F E Gump; J M Kinney; P J Mulrow
Journal:  Proc Soc Exp Biol Med       Date:  1974-10

5.  Portal and peripheral vein immunoreactive glucagon concentrations after arginine or glucose infusions.

Authors:  W G Blackard; N C Nelson; S S Andrews
Journal:  Diabetes       Date:  1974-03       Impact factor: 9.461

6.  Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance.

Authors:  W A Müller; G R Faloona; R H Unger
Journal:  Am J Med       Date:  1973-01       Impact factor: 4.965

7.  Splanchnic glucose and amino acid metabolism in obesity.

Authors:  P Felig; J Wahren; R Hendler; T Brundin
Journal:  J Clin Invest       Date:  1974-02       Impact factor: 14.808

8.  Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects.

Authors:  R S Sherwin; M Fisher; R Hendler; P Felig
Journal:  N Engl J Med       Date:  1976-02-26       Impact factor: 91.245

9.  Glucagon levels and metabolic effects in fasting man.

Authors:  E B Marliss; T T Aoki; R H Unger; J S Soeldner; G F Cahill
Journal:  J Clin Invest       Date:  1970-12       Impact factor: 14.808

10.  A model of the kinetics of insulin in man.

Authors:  R S Sherwin; K J Kramer; J D Tobin; P A Insel; J E Liljenquist; M Berman; R Andres
Journal:  J Clin Invest       Date:  1974-05       Impact factor: 14.808
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  21 in total

1.  Pharmacokinetics modeling of exogenous glucagon in type 1 diabetes mellitus patients.

Authors:  Dayu Lv; Marc D Breton; Leon S Farhy
Journal:  Diabetes Technol Ther       Date:  2013-08-26       Impact factor: 6.118

2.  The role of the liver in glucagon metabolism.

Authors:  J B Jaspan; A H Huen; C G Morley; A R Moossa; A H Rubenstein
Journal:  J Clin Invest       Date:  1977-08       Impact factor: 14.808

3.  Changes in plasma glucagon and insulin associated with fasting in sea bass (Dicentrarchus labrax).

Authors:  J Gutiérrez; J Pérez; I Navarro; S Zanuy; M Carrillo
Journal:  Fish Physiol Biochem       Date:  1991-04       Impact factor: 2.794

4.  Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.

Authors:  Ele Ferrannini; Elza Muscelli; Silvia Frascerra; Simona Baldi; Andrea Mari; Tim Heise; Uli C Broedl; Hans-Juergen Woerle
Journal:  J Clin Invest       Date:  2014-01-27       Impact factor: 14.808

5.  Glucagon metabolism in the rat.

Authors:  D S Emmanouel; J B Jaspan; A H Rubenstein; A H Huen; E Fink; A I Katz
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

6.  Extrapancreatic glucagon and glucagonlike immunoreactivity in depancreatized dogs. A quantitative assessment of secretion rates and anatomical delineation of sources.

Authors:  W A Muller; L Girardier; J Seydoux; M Berger; A E Renold; M Vranic
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

7.  Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding.

Authors:  R A DeFronzo; V Soman; R S Sherwin; R Hendler; P Felig
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

8.  Regulation of coenzyme A biosynthesis by glucagon and glucocorticoid in adult rat liver parenchymal cells.

Authors:  C M Smith; C R Savage
Journal:  Biochem J       Date:  1980-04-15       Impact factor: 3.857

9.  Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine.

Authors:  M D Jensen; M W Haymond; J E Gerich; P E Cryer; J M Miles
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

10.  A mathematical model of brain glucose homeostasis.

Authors:  Lu Gaohua; Hidenori Kimura
Journal:  Theor Biol Med Model       Date:  2009-11-27       Impact factor: 2.432
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