Literature DB >> 10639581

TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells.

T Koyama1, M Yashiro, T Inoue, S Nishimura, K Hirakawa-YS Chung.   

Abstract

Gastric fibroblast-derived conditioned medium and TGF-beta1 stimulated the adhesion ability of scirrhous gastric cancer cells to mesothelial cells, but not that of well-differentiated gastric cancer cells. The CD44H expression of scirrhous gastric cancer cells was significantly up-regulated by gastric fibroblast-derived CM and TGF-beta1. The stimulated adhesion ability and CD44H expression was significantly inhibited by anti TGF-beta1 neutralizing antibody. These findings suggested that TGF-beta1 secreted by gastric fibroblasts up-regulated the CD44H expression of scirrhous gastric cancer cells, which resulted in the stimulation of the adhesion ability of scirrhous gastric cancer cells to the mesothelium, and increased the peritoneal dissemination potential. These results might explain one of the reasons why scirrhous gastric carcinomas develop frequent peritoneal dissemination.

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Year:  2000        PMID： 10639581     DOI： 10.3892/ijo.16.2.355

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  9 in total

1.  Cancer-stromal interactions in scirrhous gastric carcinoma.

Authors:  Masakazu Yashiro; Kosei Hirakawa
Journal:  Cancer Microenviron       Date:  2010-01-26

2.  Borrmann type IV: an independent prognostic factor for survival in gastric cancer.

Authors:  Ji Yeong An; Tae Ho Kang; Min Gew Choi; Jae Hyung Noh; Tae Sung Sohn; Sung Kim
Journal:  J Gastrointest Surg       Date:  2008-05-31       Impact factor: 3.452

3.  Limited significance of curative surgery in Borrmann type IV gastric cancer.

Authors:  Eun Young Kim; Han Mo Yoo; Kyo Young Song; Cho Hyun Park
Journal:  Med Oncol       Date:  2016-06-01       Impact factor: 3.064

4.  Prognosis prediction model for a special entity of gastric cancer, linitis plastica.

Authors:  Xinhua Chen; Yunfei Zhi; Zhousheng Lin; Jinyuan Ma; Weiming Mou; Jiang Yu
Journal:  J Gastrointest Oncol       Date:  2021-04

5.  Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line.

Authors:  Yasumichi Yagi; Sachio Fushida; Shinichi Harada; Jun Kinoshita; Isamu Makino; Katsunobu Oyama; Hidehiro Tajima; Hideto Fujita; Hiroyuki Takamura; Itasu Ninomiya; Takashi Fujimura; Tetsuo Ohta; Masakazu Yashiro; Kosei Hirakawa
Journal:  J Exp Clin Cancer Res       Date:  2010-11-17

Review 6.  Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion.

Authors:  Hideki Yamaguchi; Ryuichi Sakai
Journal:  Cancers (Basel)       Date:  2015-10-14       Impact factor: 6.639

7.  Low-dose paclitaxel modulates tumour fibrosis in gastric cancer.

Authors:  Tomoya Tsukada; Sachio Fushida; Shinichi Harada; Shiroh Terai; Yasumichi Yagi; Jun Kinoshita; Katsunobu Oyama; Hidehiro Tajima; Itasu Ninomiya; Takashi Fujimura; Tetsuo Ohta
Journal:  Int J Oncol       Date:  2013-01-29       Impact factor: 5.650

8.  Low-dose eribulin mesylate exerts antitumor effects in gastric cancer by inhibiting fibrosis via the suppression of epithelial-mesenchymal transition and acts synergistically with 5-fluorouracil.

Authors:  Toru Kurata; Sachio Fushida; Jun Kinoshita; Katsunobu Oyama; Takahisa Yamaguchi; Mitsuyoshi Okazaki; Tomoharu Miyashita; Hidehiro Tajima; Itasu Ninomiya; Tetsuo Ohta
Journal:  Cancer Manag Res       Date:  2018-08-15       Impact factor: 3.989

Review 9.  Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer.

Authors:  Yuichiro Miki; Masakazu Yashiro; Lidia Moyano-Galceran; Atsushi Sugimoto; Masaichi Ohira; Kaisa Lehti
Journal:  Front Oncol       Date:  2020-10-16       Impact factor: 6.244
  9 in total

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