OBJECTIVES: The study investigated the potential role of eight candidate genes in the susceptibility to idiopathic dilated cardiomyopathy (IDC). BACKGROUND: Idiopathic dilated cardiomyopathy has a familial origin in 20% to 25% of cases, and several genetic loci have been identified in rare monogenic forms of the disease. These findings led to the hypothesis that genetic factors might also be involved in sporadic forms of the disease. In complex diseases that do not exhibit a clear pattern of familial aggregation, the candidate gene approach is a strategy widely used to identify susceptibility genes. All genes coding for proteins involved in biochemical or physiological abnormalities of cardiac function are potential candidates for IDC. METHODS: We studied 433 patients with IDC and 401 gender- and age-matched controls. Polymorphisms investigated were the I/D polymorphism of the angiotensin I-converting enzyme (ACE) gene, the T174M and M235T polymorphisms of the angiotensinogen (AGT) gene, the A-153G and A+39C polymorphisms of the angiotensin-II type 1 receptor (AGTR1) gene, the T-344C polymorphism of the aldosterone synthase (CYP11B2) gene, the G-308A polymorphism of the tumor necrosis factor-alpha (TNF) gene, the R25P polymorphism of the transforming growth factor beta1 (TGFB1) gene, the G+11/in23T polymorphism of the endothelial nitric oxide synthase (NOS3) gene and the C-1563T polymorphism of the brain natriuretic peptide (BNP) gene. RESULTS: None of the polymorphisms were significantly associated with the risk or the severity of the disease. CONCLUSIONS: We did not find evidence for an involvement of any of the 10 investigated polymorphisms in the susceptibility to IDC.
OBJECTIVES: The study investigated the potential role of eight candidate genes in the susceptibility to idiopathic dilated cardiomyopathy (IDC). BACKGROUND:Idiopathic dilated cardiomyopathy has a familial origin in 20% to 25% of cases, and several genetic loci have been identified in rare monogenic forms of the disease. These findings led to the hypothesis that genetic factors might also be involved in sporadic forms of the disease. In complex diseases that do not exhibit a clear pattern of familial aggregation, the candidate gene approach is a strategy widely used to identify susceptibility genes. All genes coding for proteins involved in biochemical or physiological abnormalities of cardiac function are potential candidates for IDC. METHODS: We studied 433 patients with IDC and 401 gender- and age-matched controls. Polymorphisms investigated were the I/D polymorphism of the angiotensin I-converting enzyme (ACE) gene, the T174M and M235T polymorphisms of the angiotensinogen (AGT) gene, the A-153G and A+39C polymorphisms of the angiotensin-II type 1 receptor (AGTR1) gene, the T-344C polymorphism of the aldosterone synthase (CYP11B2) gene, the G-308A polymorphism of the tumor necrosis factor-alpha (TNF) gene, the R25P polymorphism of the transforming growth factor beta1 (TGFB1) gene, the G+11/in23T polymorphism of the endothelial nitric oxide synthase (NOS3) gene and the C-1563T polymorphism of the brain natriuretic peptide (BNP) gene. RESULTS: None of the polymorphisms were significantly associated with the risk or the severity of the disease. CONCLUSIONS: We did not find evidence for an involvement of any of the 10 investigated polymorphisms in the susceptibility to IDC.
Authors: Jo El J Schultz; Sandra A Witt; Betty J Glascock; Michelle L Nieman; Peter J Reiser; Stacey L Nix; Thomas R Kimball; Thomas Doetschman Journal: J Clin Invest Date: 2002-03 Impact factor: 14.808
Authors: E Takai; H Akita; K Kanazawa; N Shiga; M Terashima; Y Matsuda; C Iwai; Y Miyamoto; H Kawai; A Takarada; M Yokoyama Journal: Heart Date: 2002-12 Impact factor: 5.994
Authors: Eric Villard; Claire Perret; Françoise Gary; Carole Proust; Gilles Dilanian; Christian Hengstenberg; Volker Ruppert; Eloisa Arbustini; Thomas Wichter; Marine Germain; Olivier Dubourg; Luigi Tavazzi; Marie-Claude Aumont; Pascal DeGroote; Laurent Fauchier; Jean-Noël Trochu; Pierre Gibelin; Jean-François Aupetit; Klaus Stark; Jeanette Erdmann; Roland Hetzer; Angharad M Roberts; Paul J R Barton; Vera Regitz-Zagrosek; Uzma Aslam; Laëtitia Duboscq-Bidot; Matthias Meyborg; Bernhard Maisch; Hugo Madeira; Anders Waldenström; Enrique Galve; John G Cleland; Richard Dorent; Gerard Roizes; Tanja Zeller; Stefan Blankenberg; Alison H Goodall; Stuart Cook; David A Tregouet; Laurence Tiret; Richard Isnard; Michel Komajda; Philippe Charron; François Cambien Journal: Eur Heart J Date: 2011-04-01 Impact factor: 29.983
Authors: Marcin Zakrzewski-Jakubiak; Simon de Denus; Marie-Pierre Dubé; François Bélanger; Michel White; Jacques Turgeon Journal: Br J Clin Pharmacol Date: 2008-02-12 Impact factor: 4.335