C Dalman1, J Cullberg. 1. Stockholm County Child and Adolescent Public Health Unit (CBU), Huddinge, Sweden.
Abstract
OBJECTIVE: Various studies have shown an association between obstetric complications and psychiatric illness. There is a lack of specific aetiological explanations. A possible mechanism contributing to cerebral vulnerability is neonatal hyperbilirubinaemia (NHB). METHOD: A total of 509 children with NHB (bilirubin > 15 mg %) were compared with the same number of controls (matched for gender, place of residence, and date and place of birth) with respect to in-patient psychiatric care during 1971-1993. RESULTS: A significantly greater number of individuals in the NHB group received in-patient psychiatric care than in the control group (OR, 2.5; 95% CI, 1.1-5.5). After exclusion of infants with associated obstetric risk factors, the significantly increased risk for in-patient psychiatric care still remained among the children with NHB (OR, 13.4; 95% CI, 1.6-110.1). CONCLUSION: NHB could be a factor underlying subsequent development of mental ill-health, but larger samples are needed to obtain a more reliable assessment.
OBJECTIVE: Various studies have shown an association between obstetric complications and psychiatric illness. There is a lack of specific aetiological explanations. A possible mechanism contributing to cerebral vulnerability is neonatal hyperbilirubinaemia (NHB). METHOD: A total of 509 children with NHB (bilirubin > 15 mg %) were compared with the same number of controls (matched for gender, place of residence, and date and place of birth) with respect to in-patientpsychiatric care during 1971-1993. RESULTS: A significantly greater number of individuals in the NHB group received in-patientpsychiatric care than in the control group (OR, 2.5; 95% CI, 1.1-5.5). After exclusion of infants with associated obstetric risk factors, the significantly increased risk for in-patientpsychiatric care still remained among the children with NHB (OR, 13.4; 95% CI, 1.6-110.1). CONCLUSION: NHB could be a factor underlying subsequent development of mental ill-health, but larger samples are needed to obtain a more reliable assessment.
Authors: Maria A Brito; Ana R Vaz; Sandra L Silva; Ana S Falcão; Adelaide Fernandes; Rui F M Silva; Dora Brites Journal: Mol Med Date: 2010-06-30 Impact factor: 6.354
Authors: Adelaide Fernandes; Ana Sofia Falcão; Elsa Abranches; Evguenia Bekman; Domingos Henrique; Lorene M Lanier; Dora Brites Journal: Dev Neurobiol Date: 2009-08 Impact factor: 3.964