Literature DB >> 10623771

The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression.

A K Gupta1, V Ruvolo, C Patterson, S Swaminathan.   

Abstract

Homologs of the Epstein-Barr virus (EBV) SM protein exist in several human and nonhuman herpesviruses. Structure and function differ significantly among these proteins. We have cloned and characterized the human herpesvirus 8 (HHV8) gene, KS-SM, which is homologous to the EBV SM and herpes simplex virus ICP27 genes, from an HHV8-infected primary effusion lymphoma. KS-SM is shown to be a posttranscriptional activator of gene expression in cotransfection studies. KS-SM activated gene expression in a gene-specific, promoter-independent manner. In particular, KS-SM enhanced the expression of KDR/flk-1, a receptor for vascular endothelial growth factor (VEGF), in cotransfection studies. Since expression of KDR/flk-1 is increased in Kaposi's sarcoma and HHV8-infected cell cultures and VEGF enhances the proliferation of HHV8-infected cells, KS-SM may play a pathogenic role in Kaposi's sarcoma.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10623771      PMCID： PMC111629          DOI： 10.1128/jvi.74.2.1038-1044.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  58 in total

1.  The Epstein-Barr virus immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent.

Authors:  S Kenney; J Kamine; E Holley-Guthrie; E C Mar; J C Lin; D Markovitz; J Pagano
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

2.  The Epstein-Barr virus (EBV) early protein EB2 is a posttranscriptional activator expressed under the control of EBV transcription factors EB1 and R.

Authors:  M Buisson; E Manet; M C Trescol-Biemont; H Gruffat; B Durand; A Sergeant
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

3.  The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

Authors:  W H Landschulz; P F Johnson; S L McKnight
Journal:  Science       Date:  1988-06-24       Impact factor: 47.728

4.  The role of the leucine zipper in the fos-jun interaction.

Authors:  T Kouzarides; E Ziff
Journal:  Nature       Date:  1988-12-15       Impact factor: 49.962

5.  Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient.

Authors:  A M McCarthy; L McMahan; P A Schaffer
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

6.  Conservation of sequence and function between the product of the 52-kilodalton immediate-early gene of herpesvirus saimiri and the BMLF1-encoded transcriptional effector (EB2) of Epstein-Barr virus.

Authors:  J Nicholas; U A Gompels; M A Craxton; R W Honess
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

7.  Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27.

Authors:  S A Rice; D M Knipe
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

8.  The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection.

Authors:  M A Hardwicke; R M Sandri-Goldin
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

9.  UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression.

Authors:  M Winkler; S A Rice; T Stamminger
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

10.  Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

Authors:  A Chevallier-Greco; E Manet; P Chavrier; C Mosnier; J Daillie; A Sergeant
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598
View more
  32 in total

1.  Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA.

Authors:  V Ruvolo; A K Gupta; S Swaminathan
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

2.  The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression.

Authors:  Vivian Ruvolo; Lorena Navarro; Clare E Sample; Michael David; Seung Sung; Sankar Swaminathan
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

Review 3.  Split genes and their expression in Kaposi's sarcoma-associated herpesvirus.

Authors:  Zhi-Ming Zheng
Journal:  Rev Med Virol       Date:  2003 May-Jun       Impact factor: 6.989

4.  Functional analysis of Epstein-Barr virus SM protein: identification of amino acids essential for structure, transactivation, splicing inhibition, and virion production.

Authors:  Vivian Ruvolo; Liang Sun; Karilynn Howard; Seung Sung; Henri-Jacques Delecluse; Wolfgang Hammerschmidt; Sankar Swaminathan
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

5.  Identification and Characterization of the Physiological Gene Targets of the Essential Lytic Replicative Epstein-Barr Virus SM Protein.

Authors:  Jacob Thompson; Dinesh Verma; DaJiang Li; Tim Mosbruger; Sankar Swaminathan
Journal:  J Virol       Date:  2015-11-11       Impact factor: 5.103

6.  Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein.

Authors:  Diana Palmeri; Sophia Spadavecchia; Kyla Driscoll Carroll; David M Lukac
Journal:  J Virol       Date:  2007-10-03       Impact factor: 5.103

7.  Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion.

Authors:  Jasmina Omerović; Richard Longnecker
Journal:  Virology       Date:  2007-05-02       Impact factor: 3.616

8.  Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.

Authors:  Brooke B Sahin; Denish Patel; Nicholas K Conrad
Journal:  PLoS Pathog       Date:  2010-03-05       Impact factor: 6.823

9.  Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.

Authors:  Maria J Massimelli; Vladimir Majerciak; Michael Kruhlak; Zhi-Ming Zheng
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

10.  Multiple roles of Epstein-Barr virus SM protein in lytic replication.

Authors:  Zhao Han; Elessa Marendy; Yong-Dong Wang; Jing Yuan; Jeffery T Sample; Sankar Swaminathan
Journal:  J Virol       Date:  2007-02-07       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.