Literature DB >> 2548002

The Epstein-Barr virus immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent.

S Kenney1, J Kamine, E Holley-Guthrie, E C Mar, J C Lin, D Markovitz, J Pagano.   

Abstract

In DNA cotransfection experiments, the Epstein-Barr virus immediate-early gene product, BMLF1, stimulated the chloramphenicol acetyltransferase (CAT) activity of both latent and productive EBV promoters linked to CAT. This BMLF1-induced increase in CAT activity was out of proportion to the effect on CAT mRNA, suggesting a posttranscriptional mechanism. Furthermore, when growth hormone was used as a reporter gene instead of CAT, BMLF1 no longer functioned. Thus, the BMLF1 effect was reporter-gene dependent. The effect of the BMLF1 gene product does not then appear to be directed at promoter activation, but instead may function to increase the level of an as yet unidentified protein(s) required for Epstein-Barr virus infection.

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Year:  1989        PMID： 2548002      PMCID： PMC250982          DOI： 10.1128/JVI.63.9.3870-3877.1989

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  45 in total

1.  Effect of 12-O-tetradecanoyl-phorbol-13-acetate on the replication of Epstein-Barr virus. I. Characterization of viral DNA.

Authors:  J C Lin; J E Shaw; M C Smith; J S Pagano
Journal:  Virology       Date:  1979-11       Impact factor: 3.616

2.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

3.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

4.  Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

Authors:  J Favaloro; R Treisman; R Kamen
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

5.  Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.

Authors:  L A Laimins; G Khoury; C Gorman; B Howard; P Gruss
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

6.  Transcriptional control signals of a eukaryotic protein-coding gene.

Authors:  S L McKnight; R Kingsbury
Journal:  Science       Date:  1982-07-23       Impact factor: 47.728

7.  Epstein-Barr virus RNA VII: size and direction of transcription of virus-specified cytoplasmic RNAs in a transformed cell line.

Authors:  V van Santen; A Cheung; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

8.  Epstein-Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line.

Authors:  W King; A L Thomas-Powell; N Raab-Traub; M Hawke; E Kieff
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103

9.  Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection, and interference.

Authors:  G Miller; J Robinson; L Heston; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

10.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272
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  40 in total

1.  Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression.

Authors:  S M Boyle; V Ruvolo; A K Gupta; S Swaminathan
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

2.  The C-terminal region but not the Arg-X-Pro repeat of Epstein-Barr virus protein EB2 is required for its effect on RNA splicing and transport.

Authors:  M Buisson; F Hans; I Kusters; N Duran; A Sergeant
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

3.  Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA.

Authors:  V Ruvolo; A K Gupta; S Swaminathan
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

4.  The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression.

Authors:  Vivian Ruvolo; Lorena Navarro; Clare E Sample; Michael David; Seung Sung; Sankar Swaminathan
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

5.  Functional analysis of Epstein-Barr virus SM protein: identification of amino acids essential for structure, transactivation, splicing inhibition, and virion production.

Authors:  Vivian Ruvolo; Liang Sun; Karilynn Howard; Seung Sung; Henri-Jacques Delecluse; Wolfgang Hammerschmidt; Sankar Swaminathan
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

6.  The Epstein-Barr virus (EBV) nuclear antigen 1 BamHI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle.

Authors:  A L Lear; M Rowe; M G Kurilla; S Lee; S Henderson; E Kieff; A B Rickinson
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

7.  Regulation of the Epstein-Barr virus DNA polymerase gene.

Authors:  F B Furnari; M D Adams; J S Pagano
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

8.  Marked variation in response of consensus binding elements for the Rta protein of Epstein-Barr virus.

Authors:  Lee-Wen Chen; Pey-Jium Chang; Henri-Jacques Delecluse; George Miller
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

9.  Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.

Authors:  C R Brown; M S Nakamura; J D Mosca; G S Hayward; S E Straus; L P Perera
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression.

Authors:  M Winkler; S A Rice; T Stamminger
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103
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