Literature DB >> 10611318

Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes.

A Glick1, N Popescu, V Alexander, H Ueno, E Bottinger, S H Yuspa.   

Abstract

Genetic inactivation of the transforming growth factor-beta (TGF-beta) signaling pathway can accelerate tumor progression in the mouse epidermal model of multistage carcinogenesis. By using an in vitro model of keratinocyte transformation that parallels in vivo malignant conversion to squamous cell carcinoma, we show that v-ras(Ha) transduced primary TGF-beta1-/- keratinocytes and keratinocytes expressing a TGF-beta type II dominant-negative receptor transgene have significantly higher frequencies of spontaneous transformation than control genotypes. Malignant transformation in the TGF-beta1-/- keratinocytes is preceded by aneuploidy and accumulation of chromosomal aberrations. Similarly, transient inactivation of TGF-beta signaling with a type II dominant-negative receptor adenovirus causes rapid changes in ploidy. Exogenous TGF-beta1 can suppress aneuploidy, chromosome breaks, and malignant transformation of the TGF-beta1-/- keratinocytes at concentrations that do not significantly arrest cell proliferation. These results point to genomic instability as a mechanism by which defects in TGF-beta signaling could accelerate tumor progression in mouse multistage carcinogenesis.

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Year:  1999        PMID： 10611318      PMCID： PMC24753          DOI： 10.1073/pnas.96.26.14949

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  46 in total

1.  An improved procedure for chromosome preparations from solid tumors.

Authors:  D B Zimonjic; N C Popescu
Journal:  Cancer Genet Cytogenet       Date:  1994-02

2.  Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes.

Authors:  K Münger; J A Pietenpol; M R Pittelkow; J T Holt; H L Moses
Journal:  Cell Growth Differ       Date:  1992-05

3.  Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

Authors:  A B Glick; A B Kulkarni; T Tennenbaum; H Hennings; K C Flanders; M O'Reilly; M B Sporn; S Karlsson; S H Yuspa
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

4.  Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA.

Authors:  P Seth; M Rosenfeld; J Higginbotham; R G Crystal
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103

5.  A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

Authors:  M B Kastan; Q Zhan; W S el-Deiry; F Carrier; T Jacks; W V Walsh; B S Plunkett; B Vogelstein; A J Fornace
Journal:  Cell       Date:  1992-11-13       Impact factor: 41.582

6.  DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.

Authors:  S A Hahn; M Schutte; A T Hoque; C A Moskaluk; L T da Costa; E Rozenblum; C L Weinstein; A Fischer; C J Yeo; R H Hruban; S E Kern
Journal:  Science       Date:  1996-01-19       Impact factor: 47.728

7.  Loss of receptors for transforming growth factor beta in human T-cell malignancies.

Authors:  M E Kadin; M W Cavaille-Coll; R Gertz; J Massagué; S Cheifetz; D George
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

8.  Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor beta 1.

Authors:  D Danielpour
Journal:  J Immunol Methods       Date:  1993-01-14       Impact factor: 2.303

9.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Authors:  A B Kulkarni; C G Huh; D Becker; A Geiser; M Lyght; K C Flanders; A B Roberts; M B Sporn; J M Ward; S Karlsson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

10.  p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

Authors:  G J Hannon; D Beach
Journal:  Nature       Date:  1994-09-15       Impact factor: 49.962
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  12 in total

1.  Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.

Authors:  Rolando Pérez-Lorenzo; Lauren Mordasky Markell; Kelly A Hogan; Stuart H Yuspa; Adam B Glick
Journal:  Carcinogenesis       Date:  2010-02-19       Impact factor: 4.944

2.  Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.

Authors:  Jian Chen; Sobia Zaidi; Shuyun Rao; Jiun-Sheng Chen; Liem Phan; Patrizia Farci; Xiaoping Su; Kirti Shetty; Jon White; Fausto Zamboni; Xifeng Wu; Asif Rashid; Nagarajan Pattabiraman; Raja Mazumder; Anelia Horvath; Ray-Chang Wu; Shulin Li; Cuiying Xiao; Chu-Xia Deng; David A Wheeler; Bibhuti Mishra; Rehan Akbani; Lopa Mishra
Journal:  Gastroenterology       Date:  2017-09-15       Impact factor: 22.682

Review 3.  Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma.

Authors:  Avijit Majumdar; Steven A Curley; Xifeng Wu; Powel Brown; Jessica P Hwang; Kirti Shetty; Zhi-Xing Yao; Aiwu Ruth He; Shulin Li; Lior Katz; Patrizia Farci; Lopa Mishra
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-06-19       Impact factor: 46.802

Review 4.  It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.

Authors:  M H Barcellos-Hoff
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-04       Impact factor: 2.673

5.  Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability.

Authors:  Jian Chen; Vivek Shukla; Patrizia Farci; Jaclyn Andricovich; Wilma Jogunoori; Lawrence N Kwong; Lior H Katz; Kirti Shetty; Asif Rashid; Xiaoping Su; Jon White; Lei Li; Alan Yaoqi Wang; Boris Blechacz; Gottumukkala S Raju; Marta Davila; Bao-Ngoc Nguyen; John R Stroehlein; Junjie Chen; Sang Soo Kim; Heather Levin; Keigo Machida; Hidekazu Tsukamoto; Peter Michaely; Alexandros Tzatsos; Bibhuti Mishra; Richard Amdur; Lopa Mishra
Journal:  Hepatology       Date:  2016-12-24       Impact factor: 17.425

6.  TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes.

Authors:  Saie Mogre; Nicholas Blazanin; Hailey Walsh; Jack Ibinson; Chase Minnich; Chih-Chi Andrew Hu; Adam B Glick
Journal:  Mol Carcinog       Date:  2022-08-17       Impact factor: 5.139

7.  TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.

Authors:  Patty Trobridge; Sue Knoblaugh; M Kay Washington; Nina M Munoz; Karen D Tsuchiya; Andres Rojas; Xiaoling Song; Cornelia M Ulrich; Takehiko Sasazuki; Senji Shirasawa; William M Grady
Journal:  Gastroenterology       Date:  2009-02-04       Impact factor: 22.682

8.  β2-spectrin depletion impairs DNA damage repair.

Authors:  Nobuo Horikoshi; Raj K Pandita; Kalpana Mujoo; Shashank Hambarde; Dharmendra Sharma; Abid R Mattoo; Sharmistha Chakraborty; Vijaya Charaka; Clayton R Hunt; Tej K Pandita
Journal:  Oncotarget       Date:  2016-06-07

9.  Genomic instability and colon carcinogenesis: from the perspective of genes.

Authors:  Chinthalapally V Rao; Hiroshi Y Yamada
Journal:  Front Oncol       Date:  2013-05-21       Impact factor: 6.244

10.  Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression.

Authors:  Hiroyuki Sonegawa; Takamasa Nukui; Dai-Wei Li; Mikiro Takaishi; Masakiyo Sakaguchi; Nam-Ho Huh
Journal:  J Mol Med (Berl)       Date:  2007-05-03       Impact factor: 5.606
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