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Literature DB >> 1061069

Lambda repressor turns off transcription of its own gene.

Abstract

We report transcription in vitro of the lambda repressor gene, cI, using specific restriction endonuclease fragments as templates. This transcription is repressed by lambda repressor. Moreover, we report the sequence change caused by a cI promoter mutation. This change is located between two repressor binding sites in the rightward operator (OR). Transcription studies using mutant templates indicate that repressor bound to two sites in OR regulates transcription of gene tof, and repressor bound to the remaining site(s) controls transcription of cI.

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Year: 1975 PMID： 1061069 PMCID： PMC388816 DOI： 10.1073/pnas.72.12.4785

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

1. Sequence of the PR promoter of phage lambda.

Authors: A Walz; V Pirrotta
Journal: Nature Date: 1975-03-13 Impact factor: 49.962

2. Control elements in the DNA of bacteriophage lambda.

Authors: T Maniatis; M Ptashne; R Maurer
Journal: Cold Spring Harb Symp Quant Biol Date: 1974

3. Structure of the lambda operators.

Authors: T Maniatis; M Ptashne
Journal: Nature Date: 1973-11-16 Impact factor: 49.962

4. Genetic characterization of a prm- mutant of bacteriophage lambda.

Authors: K M Yen; G N Gussin
Journal: Virology Date: 1973-11 Impact factor: 3.616

5. Multiple repressor binding at the operators in bacteriophage lambda.

Authors: T Maniatis; M Ptashne
Journal: Proc Natl Acad Sci U S A Date: 1973-05 Impact factor: 11.205

6. Termination factor for RNA synthesis.

Authors: J W Roberts
Journal: Nature Date: 1969-12-20 Impact factor: 49.962

7. Mutations in the right operator of bacteriophage lambda: evidence for operator-promoter interpenetration.

Authors: G W Ordal; A D Kaiser
Journal: J Mol Biol Date: 1973-10-05 Impact factor: 5.469

8. In vitro repression of RNA synthesis by purified lambda phage repressor.

Authors: R A Steinberg; M Ptashne
Journal: Nat New Biol Date: 1971-03-17

9. Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda.

Authors: T Maniatis; M Ptashne; K Backman; D Kield; S Flashman; A Jeffrey; R Maurer
Journal: Cell Date: 1975-06 Impact factor: 41.582

10. The nucleotide sequence of the lactose messenger ribonucleic acid transcribed from the UV5 promoter mutant of Escherichia coli.

Authors: N M Maizels
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

50 in total

1. Purification and properties of a DNA-binding protein with characteristics expected for the Cro protein of bacteriophage lambda, a repressor essential for lytic growth.

Authors: A Folkmanis; Y Takeda; J Simuth; G Gussin; H Echols
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

9. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen.

Authors: G Khoury; E May
Journal: J Virol Date: 1977-07 Impact factor: 5.103

10. Purification and properties of a lambda operator-binding protein which is expected to be autorepressor (tof protein) from E. coli carrying lambdadv plasmid.

Authors: T Murotsu; H Tanaka; M Imaji; H Koga; K Matsubara; T Horiuchi
Journal: Mol Gen Genet Date: 1977-11-29

Lambda repressor turns off transcription of its own gene.

1. Sequence of the PR promoter of phage lambda.

2. Control elements in the DNA of bacteriophage lambda.

3. Structure of the lambda operators.

4. Genetic characterization of a prm- mutant of bacteriophage lambda.

5. Multiple repressor binding at the operators in bacteriophage lambda.

6. Termination factor for RNA synthesis.

7. Mutations in the right operator of bacteriophage lambda: evidence for operator-promoter interpenetration.

8. In vitro repression of RNA synthesis by purified lambda phage repressor.

9. Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda.

10. The nucleotide sequence of the lactose messenger ribonucleic acid transcribed from the UV5 promoter mutant of Escherichia coli.

1. Purification and properties of a DNA-binding protein with characteristics expected for the Cro protein of bacteriophage lambda, a repressor essential for lytic growth.

2. Quantitative transcription factor binding kinetics at the single-molecule level.

3. Multilevel autoregulation of λ repressor protein CI by DNA looping in vitro.

4. DNA regions essential for the function of a bacteriophage fd promoter.

5. RNA polymerase binding sites in lambdaplac5 DNA.

6. Induction of superoxide dismutases in Escherichia coli by manganese and iron.

7. Autoregulation of the tyrR gene.

8. Overproduction of phage lambda repressor under control of the lac promotor of Escherichia coli.

9. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen.

10. Purification and properties of a lambda operator-binding protein which is expected to be autorepressor (tof protein) from E. coli carrying lambdadv plasmid.