Literature DB >> 10609782

Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells.

L Lagneaux1, A Delforge, C De Bruyn, M Bernier, D Bron.   

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal long-lived B cells which are apparently resistant to normal apoptotic regulation. Since bone marrow stromal cells play an essential role in B lymphopoiesis, we have investigated whether stromal cells influence B-CLL cell survival. Our results indicate that intimate contact with stromal cells reduces B-CLL cell apoptosis and prevents the loss of bcl-2 protein expression. Binding of B-CLL cells to stromal cells requires simultaneous action of beta1 and beta2 integrins. The interaction between B-CLL cells and other cell types seems important for their survival and may represent an important mechanism underlying accumulation of malignant cells in B-CLL patients.

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Year:  1999        PMID： 10609782     DOI： 10.1080/10428199909169609

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  23 in total

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