| Literature DB >> 17241660 |
Neil E Kay1, Tait D Shanafelt, Ann K Strege, Yean K Lee, Nancy D Bone, Azra Raza.
Abstract
A novel bone biopsy technique was used to generate a robust stromal cell system to study how stroma modulates CLL B-cell apoptosis and how the leukemic cell-stromal interaction influences secretion of vascular factors. Marrow stromal elements (MSE) rescued CLL B-cells from both spontaneous and drug induced apoptosis, partly due to soluble factors. When CLL B-cells were added to the MSE cultures, a dramatic increase in the secretion of basic fibroblast growth factor and decrease in the secretion of thrombospondin was observed. These results indicate the interaction between CLL B-cells and marrow stromal elements regulates angiogenic switching and may be linked to disease progression.Entities:
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Year: 2007 PMID： 17241660 PMCID： PMC2505044 DOI： 10.1016/j.leukres.2006.11.024
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156