Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know.

Advances in our knowledge of the biochemistry of coagulation and fibrinolysis have facilitated the development of sensitive and specific assays that detect platelet activation, the generation of coagulation enzymes, and products of intravascular fibrin formation and dissolution. This review focuses on activation markers of blood coagulation and, in particular, on mechanistic information on the pathophysiology of blood coagulation they have provided. The methodological problems faced in employing these moieties in clinical studies are examined. Only the proper use of coagulation activation markers will enable us to establish their real clinical usefulness.