Literature DB >> 10605742

The role of genetics in inhibitor formation.

J C Gill1.   

Abstract

Previous studies in humans and animal models, as well as the analysis of data collected for this study, appear to strongly support the role of genetic factors in the formation of inhibitors, in addition to the specific underlying factor VIII mutation. The elucidation of novel genes important to inhibitor development has the potential to lead to improved understanding of the pathogenic mechanisms underlying this immune response in humans and, ultimately, to the development of new approaches to prevention or treatment of this serious complication of hemophilia.

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Year:  1999        PMID： 10605742

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN： 0340-6245            Impact factor:   5.249


  9 in total

Review 1.  Violating the theory of single gene-single disorder: inhibitor development in hemophilia.

Authors:  Suad AlFadhli; Rasheeba Nizam
Journal:  Indian J Hematol Blood Transfus       Date:  2014-11-20       Impact factor: 0.900

Review 2.  Inhibitors of propagation of coagulation (factors VIII, IX and XI): a review of current therapeutic practice.

Authors:  Massimo Franchini; Pier Mannuccio Mannucci
Journal:  Br J Clin Pharmacol       Date:  2011-10       Impact factor: 4.335

3.  A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A.

Authors:  J N Lozier; P S Rosenberg; J J Goedert; I Menashe
Journal:  Haemophilia       Date:  2011-03-01       Impact factor: 4.287

Review 4.  FVIII inhibitors: pathogenesis and avoidance.

Authors:  Jan Astermark
Journal:  Blood       Date:  2015-02-23       Impact factor: 22.113

Review 5.  Immune tolerance therapy for haemophilia.

Authors:  A Y Ho; S E Height; M P Smith
Journal:  Drugs       Date:  2000-09       Impact factor: 9.546

6.  Emergency department use among Michigan children with special health care needs: an introductory study.

Authors:  Harold A Pollack; Kevin J Dombkowski; Janet B Zimmerman; Matthew M Davis; Anne E Cowan; John R Wheeler; A Craig Hillemeier; Gary L Freed
Journal:  Health Serv Res       Date:  2004-06       Impact factor: 3.402

7.  F8 haplotype and inhibitor risk: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.

Authors:  J Schwarz; J Astermark; E D Menius; M Carrington; S M Donfield; E D Gomperts; G W Nelson; J Oldenburg; A Pavlova; A D Shapiro; C A Winkler; E Berntorp
Journal:  Haemophilia       Date:  2012-09-07       Impact factor: 4.287

8.  Racial Differences in Chronic Pain and Quality of Life among Adolescents and Young Adults with Moderate or Severe Hemophilia.

Authors:  John M McLaughlin; Angela Lambing; Michelle L Witkop; Terry L Anderson; James Munn; Bartholomew Tortella
Journal:  J Racial Ethn Health Disparities       Date:  2015-04-03

Review 9.  Importance of immune response genes in hemophilia A.

Authors:  Josiane Bazzo de Alencar; Luciana Conci Macedo; Morgana Ferreira de Barros; Camila Rodrigues; Renata Campos Cadide; Ana Maria Sell; Jeane Eliete Laguila Visentainer
Journal:  Rev Bras Hematol Hemoter       Date:  2013
  9 in total

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