AIM: To establish the depth of Barrett's columnar epithelium and normal squamous oesophageal epithelium, in order to determine the depth of destruction required in ablation treatment for Barrett oesophagus. METHODS: Histological specimens from 100 cases of Barrett oesophagus and 100 samples of normal squamous oesophageal epithelium were studied. Using a system of multiple measurements until the change in cumulative mean values varied by less than 5%, the overall mean and normal range of depth was calculated for each type of epithelium. RESULTS: Barrett columnar epithelium is minimally thicker (mean (SEM) 0.50 (0.004) mm; range 0.39 to 0.59 mm) than normal squamous epithelium (0.49 (0.003) mm; 0.42 to 0.58 mm), although this difference is probably too small to be of clinical relevance. CONCLUSIONS: Although there are numerous clinical reports of various methods of ablation treatment for Barrett oesophagus, little attention has been paid to the depth of tissue destruction required. This is the first study to look specifically at this issue, and it provides information on the necessary depth of epithelial ablation.
AIM: To establish the depth of Barrett's columnar epithelium and normal squamous oesophageal epithelium, in order to determine the depth of destruction required in ablation treatment for Barrett oesophagus. METHODS: Histological specimens from 100 cases of Barrett oesophagus and 100 samples of normal squamous oesophageal epithelium were studied. Using a system of multiple measurements until the change in cumulative mean values varied by less than 5%, the overall mean and normal range of depth was calculated for each type of epithelium. RESULTS: Barrett columnar epithelium is minimally thicker (mean (SEM) 0.50 (0.004) mm; range 0.39 to 0.59 mm) than normal squamous epithelium (0.49 (0.003) mm; 0.42 to 0.58 mm), although this difference is probably too small to be of clinical relevance. CONCLUSIONS: Although there are numerous clinical reports of various methods of ablation treatment for Barrett oesophagus, little attention has been paid to the depth of tissue destruction required. This is the first study to look specifically at this issue, and it provides information on the necessary depth of epithelial ablation.
Authors: Corrado Pedrazzani; Filippo Catalano; Mara Festini; Germana Zerman; Anna Tomezzoli; Andrea Ruzzenente; Alfredo Guglielmi; Giovanni de Manzoni Journal: World J Gastroenterol Date: 2005-03-28 Impact factor: 5.742
Authors: R Ackroyd; N J Brown; M F Davis; T J Stephenson; S L Marcus; C J Stoddard; A G Johnson; M W Reed Journal: Gut Date: 2000-11 Impact factor: 23.059
Authors: B J Dunkin; J Martinez; P A Bejarano; C D Smith; K Chang; A S Livingstone; W S Melvin Journal: Surg Endosc Date: 2005-12-07 Impact factor: 3.453
Authors: Tsung-Han Tsai; Chao Zhou; Hsiang-Chieh Lee; Yuankai K Tao; Osman O Ahsen; Marisa Figueiredo; Desmond C Adler; Joseph M Schmitt; Qin Huang; James G Fujimoto; Hiroshi Mashimo Journal: Gastroenterol Res Pract Date: 2012-07-10 Impact factor: 2.260