Literature DB >> 10603417

ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells.

B A Cowell1, D Y Chen, D W Frank, A J Vallis, S M Fleiszig.   

Abstract

The presence of invasion-inhibitory activity that is regulated by the transcriptional activator ExsA of cytotoxic Pseudomonas aeruginosa has previously been proposed. The results of this study show that both ExoT and ExoS, known type III secreted effector proteins of P. aeruginosa that are regulated by ExsA, possess this activity. Invasion was reduced 94.4% by ExoT and 96.0% by ExoS. Invasion-inhibitory activity is not linked to ADP-ribosylation activity, at least for ExoS, since a noncatalytic mutant also inhibits uptake by an epithelial cell line (invasion was reduced 96. 0% by ExoSE381A).

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Year:  2000        PMID： 10603417      PMCID： PMC97150          DOI： 10.1128/IAI.68.1.403-406.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells.

Authors:  A J Vallis; V Finck-Barbançon; T L Yahr; D W Frank
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

2.  Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia.

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Journal:  Science       Date:  1990-08-03       Impact factor: 47.728

Review 3.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Authors:  S F Altschul; T L Madden; A A Schäffer; J Zhang; Z Zhang; W Miller; D J Lipman
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

4.  The cytotoxic protein YopE of Yersinia obstructs the primary host defence.

Authors:  R Rosqvist; A Forsberg; M Rimpiläinen; T Bergman; H Wolf-Watz
Journal:  Mol Microbiol       Date:  1990-04       Impact factor: 3.501

5.  Beta-adrenergic and serotonergic responsiveness of rabbit corneal epithelial cells in culture.

Authors:  M M Jumblatt; A H Neufeld
Journal:  Invest Ophthalmol Vis Sci       Date:  1983-08       Impact factor: 4.799

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Journal:  Mol Microbiol       Date:  1996-06       Impact factor: 3.501

7.  Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells.

Authors:  A R Hauser; S Fleiszig; P J Kang; K Mostov; J N Engel
Journal:  Infect Immun       Date:  1998-04       Impact factor: 3.441

8.  Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity.

Authors:  D J Evans; D W Frank; V Finck-Barbançon; C Wu; S M Fleiszig
Journal:  Infect Immun       Date:  1998-04       Impact factor: 3.441

9.  Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells.

Authors:  M Fällman; K Andersson; S Håkansson; K E Magnusson; O Stendahl; H Wolf-Watz
Journal:  Infect Immun       Date:  1995-08       Impact factor: 3.441

10.  Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions.

Authors:  A J Vallis; T L Yahr; J T Barbieri; D W Frank
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441
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  40 in total

1.  Traversal of multilayered corneal epithelia by cytotoxic Pseudomonas aeruginosa requires the phospholipase domain of exoU.

Authors:  Julio C Ramirez; Suzanne M J Fleiszig; Aaron B Sullivan; Connie Tam; Roya Borazjani; David J Evans
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-01-25       Impact factor: 4.799

2.  FlhA, a component of the flagellum assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells.

Authors:  S M Fleiszig; S K Arora; R Van; R Ramphal
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

3.  Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion.

Authors:  Daniel Aiello; John D Williams; Helena Majgier-Baranowska; Ishan Patel; Norton P Peet; Jin Huang; Stephen Lory; Terry L Bowlin; Donald T Moir
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

4.  Type III secretion-dependent modulation of innate immunity as one of multiple factors regulated by Pseudomonas aeruginosa RetS.

Authors:  Irandokht Zolfaghar; David J Evans; Reza Ronaghi; Suzanne M J Fleiszig
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Review 5.  Corneal ulceration in pediatric patients: a brief overview of progress in topical treatment.

Authors:  Serina Stretton; Usha Gopinathan; Mark D P Willcox
Journal:  Paediatr Drugs       Date:  2002       Impact factor: 3.022

6.  Growth phase-dependent invasion of Pseudomonas aeruginosa and its survival within HeLa cells.

Authors:  U Ha; S Jin
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

7.  Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.

Authors:  J A Lomholt; K Poulsen; M Kilian
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

8.  The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.

Authors:  L Garrity-Ryan; S Shafikhani; P Balachandran; L Nguyen; J Oza; T Jakobsen; J Sargent; X Fang; S Cordwell; M A Matthay; J N Engel
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

9.  Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa.

Authors:  Barbara I Kazmierczak; Keith Mostov; Joanne N Engel
Journal:  Mol Biol Cell       Date:  2003-10-31       Impact factor: 4.138

10.  Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo.

Authors:  Maria L Henriksson; Charlotta Sundin; Anna L Jansson; Ake Forsberg; Ruth H Palmer; Bengt Hallberg
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857
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