| Literature DB >> 10602676 |
J Y Niederkorn1, H Alizadeh, H Leher, J P McCulley.
Abstract
Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.Entities:
Mesh:
Year: 1999 PMID: 10602676 DOI: 10.1016/s1286-4579(99)80047-1
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700