Literature DB >> 10600746

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.

J Xu1, Q Deng, J Chen, K N Houk, J Bartek, D Hilvert, I A Wilson.   

Abstract

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

Mesh：

Substances：

Year:  1999        PMID： 10600746     DOI： 10.1126/science.286.5448.2345

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.

Authors:  Marina Hugot; Nicolas Bensel; Monique Vogel; Martine T Reymond; Beda Stadler; Jean-Louis Reymond; Ulrich Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-01       Impact factor: 11.205

2.  Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.

Authors:  Alexander Serganov; Sonja Keiper; Lucy Malinina; Valentina Tereshko; Eugene Skripkin; Claudia Höbartner; Anna Polonskaia; Anh Tuân Phan; Richard Wombacher; Ronald Micura; Zbigniew Dauter; Andres Jäschke; Dinshaw J Patel
Journal:  Nat Struct Mol Biol       Date:  2005-02-20       Impact factor: 15.369

3.  Selection of ribozymes that catalyse multiple-turnover Diels-Alder cycloadditions by using in vitro compartmentalization.

Authors:  Jeremy J Agresti; Bernard T Kelly; Andres Jäschke; Andrew D Griffiths
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-31       Impact factor: 11.205

Review 4.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

Review 5.  Current developments and challenges in the search for a naturally selected Diels-Alderase.

Authors:  Hak Joong Kim; Mark W Ruszczycky; Hung-wen Liu
Journal:  Curr Opin Chem Biol       Date:  2012-01-17       Impact factor: 8.822

Review 6.  Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes.

Authors:  Richard Wolfenden
Journal:  J Biol Chem       Date:  2014-09-10       Impact factor: 5.157

7.  Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.

Authors:  Nathalie Preiswerk; Tobias Beck; Jessica D Schulz; Peter Milovník; Clemens Mayer; Justin B Siegel; David Baker; Donald Hilvert
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-20       Impact factor: 11.205

8.  Computational analysis of binding of P1 variants to trypsin.

Authors:  B O Brandsdal; J Aqvist; A O Smalås
Journal:  Protein Sci       Date:  2001-08       Impact factor: 6.725

9.  Natural Diels-Alderases: Elusive and Irresistable.

Authors:  Kimberly Klas; Sachiko Tsukamoto; David H Sherman; Robert M Williams
Journal:  J Org Chem       Date:  2015-12-04       Impact factor: 4.354

10.  Light chain separated from the rest of the type a botulinum neurotoxin molecule is the most catalytically active form.

Authors:  Nizamettin Gul; Leonard A Smith; S Ashraf Ahmed
Journal:  PLoS One       Date:  2010-09-22       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.