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Literature DB >> 10599801

Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.

M O McCarron¹, K L Hoffmann, D M DeLong, L Gray, A M Saunders, M J Alberts.

Abstract

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.

Entities: Disease Gene Species

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Year: 1999 PMID： 10599801 DOI： 10.1212/wnl.53.9.2176

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

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Cited

28 in total

1. Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3-month outcome among patients with intracerebral hemorrhage: results from the antihypertensive treatment of acute cerebral hemorrhage study.

Authors: Adnan I Qureshi; Yuko Y Palesch; Reneé Martin; Jill Novitzke; Salvador Cruz-Flores; As'ad Ehtisham; Mustapha A Ezzeddine; Joshua N Goldstein; Haitham M Hussein; M Fareed K Suri; Nauman Tariq
Journal: Arch Neurol Date: 2010-05

2. Not so accidental outcomes following cerebrovascular accidents.

Authors: James F Meschia
Journal: Curr Neurol Neurosci Rep Date: 2004-09 Impact factor: 5.081

3. A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus.

Authors: Zhi-Yu Wang; Takanori Miki; Yan Ding; Shi-Jie Wang; Yu-Huan Gao; Xiao-Ling Wang; Yu-Hua Wang; Toshifumi Yokoyama; Katsuhiko Warita; Ken-ichi Ohta; Shingo Suzuki; Taira Ohnishi; Takashi Obama; Kuldip S Bedi; Yoshiki Takeuchi; Bao-En Shan
Journal: Metab Brain Dis Date: 2011-08-09 Impact factor: 3.584

4. Genes and outcome after aneurysmal subarachnoid haemorrhage.

Authors: Y M Ruigrok; A J C Slooter; A Bardoel; C J M Frijns; G J E Rinkel; C Wijmenga
Journal: J Neurol Date: 2005-02-23 Impact factor: 4.849

5. Association of serum glucose concentrations during acute hospitalization with hematoma expansion, perihematomal edema, and three month outcome among patients with intracerebral hemorrhage.

Authors: Adnan I Qureshi; Yuko Y Palesch; Renee Martin; Jill Novitzke; Salvador Cruz-Flores; Asad Ehtisham; Mustapha A Ezzeddine; Joshua N Goldstein; Jawad F Kirmani; Haitham M Hussein; M Fareed K Suri; Nauman Tariq; Yuan Liu
Journal: Neurocrit Care Date: 2011-12 Impact factor: 3.210

Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.

1. Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3-month outcome among patients with intracerebral hemorrhage: results from the antihypertensive treatment of acute cerebral hemorrhage study.

2. Not so accidental outcomes following cerebrovascular accidents.

3. A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus.

4. Genes and outcome after aneurysmal subarachnoid haemorrhage.

5. Association of serum glucose concentrations during acute hospitalization with hematoma expansion, perihematomal edema, and three month outcome among patients with intracerebral hemorrhage.

Review 6. Targeting secondary injury in intracerebral haemorrhage--perihaematomal oedema.

7. Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype.

8. Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury.

9. New avenues for treatment of intracranial hemorrhage.

Review 10. Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.