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Literature DB >> 12782758

Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.

N Nathoo¹, R Chetty, J R van Dellen, G H Barnett.

Abstract

Apolipoprotein E (APOE) is thought to be responsible for the transportation of lipids within the brain, maintaining structural integrity of the microtubule within the neurone, and assisting with neural transmission. Possession of the APOE epsilon4 allele has also been shown to influence neuropathological findings in patients who die from traumatic brain injury, including the accumulation of amyloid beta protein. Previous clinical studies reporting varying outcome severities of traumatic brain injury, including cognitive and functional recovery, all support the notion that APOE epsilon4 allele possession is associated with an unfavourable outcome. Evidence from experimental and clinical brain injury studies confirms that APOE plays an important role in the response of the brain to injury.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Apolipoproteins E

Year: 2003 PMID： 12782758 PMCID： PMC1187307 DOI： 10.1136/mp.56.3.132

Source DB: PubMed Journal: Mol Pathol ISSN： 1366-8714

70 in total

1. Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

Authors: Kunihiro Uryu; Helmut Laurer; Tracy McIntosh; Domenico Praticò; Daniel Martinez; Susan Leight; Virginia M-Y Lee; John Q Trojanowski
Journal: J Neurosci Date: 2002-01-15 Impact factor: 6.167

2. APOE genotype influences acquisition and recall following traumatic brain injury.

Authors: F C Crawford; R D Vanderploeg; M J Freeman; S Singh; M Waisman; L Michaels; L Abdullah; D Warden; R Lipsky; A Salazar; M J Mullan
Journal: Neurology Date: 2002-04-09 Impact factor: 9.910

Review 3. Apolipoprotein E alleles as risk factors in Alzheimer's disease.

Authors: A D Roses
Journal: Annu Rev Med Date: 1996 Impact factor: 13.739

4. Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy.

Authors: S M Greenberg; M E Briggs; B T Hyman; G J Kokoris; C Takis; D S Kanter; C S Kase; M S Pessin
Journal: Stroke Date: 1996-08 Impact factor: 7.914

5. High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa.

Authors: L Zekraoui; J P Lagarde; A Raisonnier; N Gérard; A Aouizérate; G Lucotte
Journal: Hum Biol Date: 1997-08 Impact factor: 0.553

6. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.

Authors: B D Jordan; N R Relkin; L D Ravdin; A R Jacobs; A Bennett; S Gandy
Journal: JAMA Date: 1997-07-09 Impact factor: 56.272

7. Effect of apolipoprotein E genotype on hematoma volume after trauma.

Authors: Imran Liaquat; Laurence T Dunn; James A R Nicoll; Graham M Teasdale; John D Norrie
Journal: J Neurosurg Date: 2002-01 Impact factor: 5.115

8. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema.

Authors: John R Lynch; Jose A Pineda; Duncan Morgan; Lin Zhang; David S Warner; Helen Benveniste; Daniel T Laskowitz
Journal: Ann Neurol Date: 2002-01 Impact factor: 10.422

9. Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures.

Authors: Irina Rozovsky; Saske Hoving; Christopher P Anderson; James O'Callaghan; Caleb E Finch
Journal: Neurosci Lett Date: 2002-05-03 Impact factor: 3.046

10. Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.

Authors: Neill R Graff-Radford; Robert C Green; Rodney C P Go; Michael L Hutton; Timi Edeki; David Bachman; Jennifer L Adamson; Patrick Griffith; Floyd B Willis; Mary Williams; Yvonne Hipps; Jonathan L Haines; L Adrienne Cupples; Lindsay A Farrer
Journal: Arch Neurol Date: 2002-04

32 in total

1. Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice.

Authors: Jessica A Siegel; Michael J Craytor; Jacob Raber
Journal: Behav Pharmacol Date: 2010-10 Impact factor: 2.293

10. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: structural MR imaging changes and apolipoprotein E genotype.

Authors: R van den Boom; S A J Lesnick Oberstein; A A van den Berg-Huysmans; M D Ferrari; M A van Buchem; J Haan
Journal: AJNR Am J Neuroradiol Date: 2006-02 Impact factor: 3.825

Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.

1. Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

2. APOE genotype influences acquisition and recall following traumatic brain injury.

Review 3. Apolipoprotein E alleles as risk factors in Alzheimer's disease.

4. Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy.

5. High frequency of the apolipoprotein E *4 allele in African pygmies and most of the African populations in sub-Saharan Africa.

6. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.

7. Effect of apolipoprotein E genotype on hematoma volume after trauma.

8. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema.

9. Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures.

10. Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.

1. Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice.

Review 2. Management of sport-related concussion in young athletes.

Review 3. [The relevance of the inflammatory response in the injured brain].

Review 4. Candidate mechanisms for chemotherapy-induced cognitive changes.

Review 5. Management of pediatric mild traumatic brain injury: a neuropsychological review from injury through recovery.

6. Impact of injury location and severity on posttraumatic epilepsy in the rat: role of frontal neocortex.

Review 7. Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery.

Review 8. Gene-environment interactions in development and disease.

Review 9. Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments.

10. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: structural MR imaging changes and apolipoprotein E genotype.