PURPOSE: This study evaluated the need for antibiotic prophylaxis in orthognathic surgery. PATIENTS AND METHODS: Fifty-four patients (age range, 18 to 40 years) underwentbimaxillary orthognatic surgery. After randomization, a placebo (n = 19), 2,200 mg amoxicillin-clavulanic acid (n = 18), or 1,500 mg cefuroxime (n = 17) was administered in a double-blind fashion. During the first month, the postoperative course was observed according to the clinical parameters of infection, total leukocyte count and erythrocyte sedimentation rate (ESR). RESULTS: Fifteen of 54 patients developed a wound infection. Of these, 10 had received a placebo; 3, cefuroxime; and 2, amoxicillin-clavulanic acid. CONCLUSIONS: There was a statistically significant (P<.004) increased risk of having an infectious complication after bimaxillary orthognathic surgery without antibiotic prophylaxis. No significant difference in the incidence of infectious complications was found between the 2 medications.
RCT Entities:
PURPOSE: This study evaluated the need for antibiotic prophylaxis in orthognathic surgery. PATIENTS AND METHODS: Fifty-four patients (age range, 18 to 40 years) underwent bimaxillary orthognatic surgery. After randomization, a placebo (n = 19), 2,200 mg amoxicillin-clavulanic acid (n = 18), or 1,500 mg cefuroxime (n = 17) was administered in a double-blind fashion. During the first month, the postoperative course was observed according to the clinical parameters of infection, total leukocyte count and erythrocyte sedimentation rate (ESR). RESULTS: Fifteen of 54 patients developed a wound infection. Of these, 10 had received a placebo; 3, cefuroxime; and 2, amoxicillin-clavulanic acid. CONCLUSIONS: There was a statistically significant (P<.004) increased risk of having an infectious complication after bimaxillary orthognathic surgery without antibiotic prophylaxis. No significant difference in the incidence of infectious complications was found between the 2 medications.
Authors: Christian I Schwer; Teresa Roth; Mathieu Gass; René Rothweiler; Torsten Loop; Marc C Metzger; Johannes Kalbhenn Journal: J Clin Med Date: 2022-07-01 Impact factor: 4.964
Authors: Mateusz Bogacz; Tadeusz Morawiec; Joanna Śmieszek-Wilczewska; Katarzyna Janowska-Bogacz; Anna Bubiłek-Bogacz; Rafał Rój; Karolina Pinocy; Anna Mertas Journal: Biomed Res Int Date: 2019-10-07 Impact factor: 3.246