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Literature DB >> 1059150

Nucleotide sequences of the 3'-terminal untranslated region of messenger RNA for human beta globin chain.

B G Forget, C A Marotta, S M Weissman, M Cohen-Solal.

Abstract

In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a frameshift mutation allowing the "readthrough" of the normal termination codon and translation of usually untranslated portions of the messenger RNA for the beta-globin chain. The oligonucleotides which match the amino-acid sequence of hemoglobin Cranston provide a sequence of 36 nucleotides which follows the normal beta-chain termination codon UAA.

Entities: Chemical Gene Species

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Year: 1975 PMID： 1059150 PMCID： PMC433046 DOI： 10.1073/pnas.72.9.3614

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

7. Development of a somatic mutation screening system using Hb mutants. IV. Successful detection of red cells containing the human frameshift mutants Hb Wayne and Hb Cranston using monospecific fluorescent antibodies.

Authors: G Stamatoyannopoulos; P E Nute; T Papayannopoulou; T McGuire; G Lim; H F Bunn; D Rucknagel
Journal: Am J Hum Genet Date: 1980-07 Impact factor: 11.025

7 in total

Nucleotide sequences of the 3'-terminal untranslated region of messenger RNA for human beta globin chain.

1. Nucleotide sequences of human globin messenger RNA.

2. Molecular weights of separated rabbit alpha-and beta-globin messenger RNAs.

3. The separation of alpha- and beta-rabbit globin mRNA by polyacrylamide gel electrophoresis.

4. Separation of alpha- and beta-globin messenger RNAs by formamide gel electrophoresis.

5. Size heterogeneity of polyadenylate sequences in mouse globin messenger RNA.

6. Haemoglobin Tak: a variant with additional residues at the end of the beta-chains.

7. The molecular weight of rabbit globin messenger RNA's.

8. Properties of mouse globin messenger ribonucleic acid and its preparation in milligram quantities.

9. Unexpectedly large size of globin messenger ribonucleic acid.

10. Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.

1. Identification of amber and ochre mutants of the human virus Ad2+ND1.

2. Hemoglobin and the genetic code. Evolution of protection against somatic mutation.

3. Practicing biochemistry without a license.

4. Nucleotide sequence from the coding region of rabbit beta-globin messenger RNA.

Review 5. The thalassemias: molecular mechanisms of human genetic disease.

Review 6. Hemoglobin variants: biochemical properties and clinical correlates.

7. Development of a somatic mutation screening system using Hb mutants. IV. Successful detection of red cells containing the human frameshift mutants Hb Wayne and Hb Cranston using monospecific fluorescent antibodies.