AIMS: Topical sunscreens are routinely applied to the skin by a large percentage of the population. This study assessed the extent of absorption of a number of common chemical sunscreen agents into and through human skin following application of commercially available products. METHODS: Sunscreen products were applied to excised human epidermis in Franz diffusion cells with the amount penetrating into and across the epidermis assessed by h.p.l.c. for 8 h following application. RESULTS: All sunscreen agents investigated penetrated into the skin (0.25 g m-2 or 14% of applied dose), but only benzophenone-3 passed through the skin in significant amounts (0.08 g m-2 or 10% of the applied dose). With one exception, suncreen agents in corresponding products marketed for adults and children had similar skin penetration profiles. CONCLUSIONS: Whilst limited absorption across the skin was observed for the majority of the sunscreens tested, benzophenone-3 demonstrated sufficiently high penetration to warrant further investigation of its continued application.
AIMS: Topical sunscreens are routinely applied to the skin by a large percentage of the population. This study assessed the extent of absorption of a number of common chemical sunscreen agents into and through human skin following application of commercially available products. METHODS: Sunscreen products were applied to excised human epidermis in Franz diffusion cells with the amount penetrating into and across the epidermis assessed by h.p.l.c. for 8 h following application. RESULTS: All sunscreen agents investigated penetrated into the skin (0.25 g m-2 or 14% of applied dose), but only benzophenone-3 passed through the skin in significant amounts (0.08 g m-2 or 10% of the applied dose). With one exception, suncreen agents in corresponding products marketed for adults and children had similar skin penetration profiles. CONCLUSIONS: Whilst limited absorption across the skin was observed for the majority of the sunscreens tested, benzophenone-3 demonstrated sufficiently high penetration to warrant further investigation of its continued application.
Authors: Ali Nasser Eddine; Jens P von Kries; Mikhail V Podust; Thulasi Warrier; Stefan H E Kaufmann; Larissa M Podust Journal: J Biol Chem Date: 2008-03-26 Impact factor: 5.157
Authors: Shereen Yousef; Xin Liu; Ahmed Mostafa; Yousuf Mohammed; Jeffrey E Grice; Yuri G Anissimov; Wedad Sakran; Michael S Roberts Journal: Pharm Res Date: 2016-06-16 Impact factor: 4.200
Authors: Lidia Mínguez-Alarcón; Yu-Han Chiu; Feiby L Nassan; Paige L Williams; John Petrozza; Jennifer B Ford; Antonia M Calafat; Russ Hauser; Jorge E Chavarro Journal: Sci Total Environ Date: 2019-05-02 Impact factor: 7.963