| Literature DB >> 10579872 |
B A Shin1, Y R Kim, I S Lee, C K Sung, J Hong, C J Sim, K S Im, J H Jung.
Abstract
A series of phospholipids, including previously undescribed compounds 4-7, were isolated by a bioactivity-guided fractionation from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis in human liver cells. These compounds were identified as lyso-PAF analogues (1-5) and lysophosphatidylcholines (6, 7) based on NMR and MS analyses. Compounds 1-7 specifically blocked the conversion of lanosterol into cholesterol in the Chang liver cell.Entities:
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Year: 1999 PMID： 10579872 DOI： 10.1021/np990303a
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050