Literature DB >> 1057772

Coezyme A requirement of malaria parasites: effects of coenzyme A precursors on extracellular development in vitro of Plasmodium lophurae.

W Trager, F H Brohn.   

Abstract

The extracellular development in vitro of the avian malaria Plasmodium lophurae is favored by addition to the medium of coenzyme A at 0.05 mM. Coenzyme A can be replaced by dephospho-coenzyme A and to some extent by phosphopantetheine, but not by phosphopantothenoylcysteine or by phosphopantothenic acid. The activity of the two former precursors results from their conversion to coenzyme A by enzymes in the erythrocyte extract of the culture medium in the presence of ATP, also an essential ingredient of the medium. Hence, P. lophurae in its erythrocytic stage has an absolute requirement for an exogenous source of coenzyme A.

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Year:  1975        PMID： 1057772      PMCID： PMC432641          DOI： 10.1073/pnas.72.5.1834

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  Malaria parasites (Plasmodium lophurae) developing extracellularly in vitro: incorporation of labeled precursors.

Authors:  W Trager
Journal:  J Protozool       Date:  1971-08

2.  Growth responses of Bifidobacterium bifidum to coenzyme A, its precursors and carrot extract.

Authors:  M Yoshioka; S Yoshioka; Z Tamura; K Ohta
Journal:  Jpn J Microbiol       Date:  1968-12

3.  The supply of cholesterol and fatty acids for the growth of mycoplasmas.

Authors:  A W Rodwell
Journal:  J Gen Microbiol       Date:  1969-09

4.  Coenzyme A and the antimalarial action in vitro of antipantothenate against Plasmodium lophurae, P. coatneyi and P. falciparum.

Authors:  W Trager
Journal:  Trans N Y Acad Sci       Date:  1966-06

5.  Pantothenic acid metabolism during avian malaria infection: pantothenate kinase activity in duck erythrocytes and in Plasmodium lophurae.

Authors:  T P Bennett; W Trager
Journal:  J Protozool       Date:  1967-05

6.  Some aspects of intracellular parasitism.

Authors:  W Trager
Journal:  Science       Date:  1974-01-25       Impact factor: 47.728

7.  DEFINED MEDIUM FOR MYCOPLASMA LAIDLAWII.

Authors:  M E TOURTELLOTTE; H J MOROWITZ; P KASIMER
Journal:  J Bacteriol       Date:  1964-07       Impact factor: 3.490

8.  Studies on the extracellular cultivation of an intracellular parasite (avian malaria). I. Development of the organisms in erythrocyte extracts, and the favoring effect of adenosinetriphosphate.

Authors:  W TRAGER
Journal:  J Exp Med       Date:  1950-10-01       Impact factor: 14.307

9.  Reversible inactivation of typhus Rickettsiae. I. Inactivation by freezing.

Authors:  M R BOVARNICK; E G ALLEN
Journal:  J Gen Physiol       Date:  1954-11-20       Impact factor: 4.086

10.  Folinic acid and non-dialyzable materials in the nutrition of malaria parasites.

Authors:  W TRAGER
Journal:  J Exp Med       Date:  1958-11-01       Impact factor: 14.307
  10 in total
  6 in total

1.  Initial extracellular development in vitro of erythrocytic stages of malaria parasites (Plasmodium falciparum).

Authors:  W Trager; J Zung; M Tershakovec
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.

Authors:  Kevin J Saliba; Isabelle Ferru; Kiaran Kirk
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

Review 3.  Lipids and the malarial parasite.

Authors:  G G Holz
Journal:  Bull World Health Organ       Date:  1977       Impact factor: 9.408

4.  Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito.

Authors:  Robert J Hart; Emmanuel Cornillot; Amanah Abraham; Emily Molina; Catherine S Nation; Choukri Ben Mamoun; Ahmed S I Aly
Journal:  Sci Rep       Date:  2016-09-20       Impact factor: 4.379

5.  Antimalarials increase vesicle pH in Plasmodium falciparum.

Authors:  D J Krogstad; P H Schlesinger; I Y Gluzman
Journal:  J Cell Biol       Date:  1985-12       Impact factor: 10.539

6.  Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito.

Authors:  Robert J Hart; Amanah Abraham; Ahmed S I Aly
Journal:  Front Cell Infect Microbiol       Date:  2017-06-20       Impact factor: 5.293
  6 in total

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