Literature DB >> 10577253

The EGF receptor as central transducer of heterologous signalling systems.

E Zwick1, P O Hackel, N Prenzel, A Ullrich.   

Abstract

The cross-talk between heterologous signalling systems of the cell represents a new dimension of complexity in the molecular communication network that governs a great variety of physiological processes. In pathophysiologically transformed cells, key elements of this network could offer unique opportunities for pharmacological intervention. In this article, the current state of knowledge regarding the role of epidermal growth factor (EGF) in such a network is described and the recent advances made in the elucidation of the mechanism underlying EGF receptor transactivation are discussed.

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Year:  1999        PMID： 10577253     DOI： 10.1016/s0165-6147(99)01373-5

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  84 in total

1.  Spatial range of autocrine signaling: modeling and computational analysis.

Authors:  S Y Shvartsman; H S Wiley; W M Deen; D A Lauffenburger
Journal:  Biophys J       Date:  2001-10       Impact factor: 4.033

2.  Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.

Authors:  Elizabeth J Joslin; Harish Shankaran; Lee K Opresko; Nikki Bollinger; Douglas A Lauffenburger; H Steven Wiley
Journal:  Mol Biosyst       Date:  2010-05-10

3.  Urea signalling to immediate-early gene transcription in renal medullary cells requires transactivation of the epidermal growth factor receptor.

Authors:  Hongyu Zhao; Wei Tian; Hongshi Xu; David M Cohen
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

4.  Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts.

Authors:  Rodrigo Franco; Ruth Lezama; Benito Ordaz; Herminia Pasantes-Morales
Journal:  Pflugers Arch       Date:  2004-01-16       Impact factor: 3.657

5.  Mitogenic signalling in the absence of epidermal growth factor receptor activation in a human glioblastoma cell line.

Authors:  Meng Wang; Patrick Maier; Frederik Wenz; Frank Anton Giordano; Carsten Herskind
Journal:  J Neurooncol       Date:  2013-12       Impact factor: 4.130

6.  A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.

Authors:  Nebojsa Andric; Mario Ascoli
Journal:  Mol Endocrinol       Date:  2006-09-14

7.  Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.

Authors:  Seok Jin Kim; Zahid N Rabbani; Fan Dong; Robin T Vollmer; Ernst-Gilbert Schreiber; Mark W Dewhirst; Zeljko Vujaskovic; Michael J Kelley
Journal:  Med Oncol       Date:  2009-02-24       Impact factor: 3.064

8.  Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.

Authors:  Jian-Hua Zhou; David V Yu; Jingwei Cheng; David J Shapiro
Journal:  Steroids       Date:  2007-07-07       Impact factor: 2.668

9.  Src family kinase involvement in rat preglomerular microvascular contractile and [Ca2+]i responses to ANG II.

Authors:  Qi Che; Pamela K Carmines
Journal:  Am J Physiol Renal Physiol       Date:  2004-11-30

10.  Epidermal-growth-factor receptor and metalloproteinases mediate thromboxane A2-dependent extracellular-signal-regulated kinase activation.

Authors:  Carole Gallet; Stéphanie Blaie; Sylviane Lévy-Toledano; Aïda Habib
Journal:  Biochem J       Date:  2003-05-01       Impact factor: 3.857
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