Literature DB >> 10573384

Effect of FR167653 on small bowel ischemia-reperfusion injury in dogs.

I Takeyoshi1, K Iwanami, S Ohwada, Y Kawashima, K Kawata, M Aiba, J Kobayashi, T Koyama, K Matsumoto, S Satoh, Y Morishita.   

Abstract

IL-1 and TNF-alpha are known to be pleiotropic cytokines associated with various inflammatory conditions such as small intestinal injury after ischemia-reperfusion. FR167653 has been characterized as a potent suppressant of IL-1 and TNF-alpha production. The effect of FR167653 on intestinal reperfusion injury was investigated in a warm ischemia model of the canine gut. Sixteen mongrel dogs were divided into two groups: a control group and a FR group to which FR167653 was administered. Both the superior mesenteric artery and vein were clamped for 2 hr. Arterial pH, hepatic venous hemoglobin oxygen saturation, intramucosal pH, and the survival rate were well maintained in the FR group in comparison with the control group after reperfusion. FR167653 inhibited the expression of IL-1beta mRNA. Histologically, ischemia-reperfusion injury was more severe in the control group than the FR group. This study suggests that FR167653 inhibits proinflammatory cytokines and ameliorates ischemia-reperfusion injury of the small intestine.

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Year:  1999        PMID： 10573384     DOI： 10.1023/a:1026633510390

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  34 in total

Review 1.  Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil.

Authors:  C R Welbourn; G Goldman; I S Paterson; C R Valeri; D Shepro; H B Hechtman
Journal:  Br J Surg       Date:  1991-06       Impact factor: 6.939

2.  Gastric intramucosal pH and hepatic venous oximetry after cardiopulmonary bypass in valve replacement patients.

Authors:  T Takahashi; F Kunimoto; H Ichikawa; S Ishikawa; Y Sato; Y Hasegawa; Y Morishita
Journal:  Cardiovasc Surg       Date:  1996-06

3.  Back-diffusion of CO2 and its influence on the intramural pH in gastric mucosa.

Authors:  R G Fiddian-Green; G Pittenger; W M Whitehouse
Journal:  J Surg Res       Date:  1982-07       Impact factor: 2.192

4.  Mucosal arachidonate metabolism and intestinal ischemia-reperfusion injury.

Authors:  M J Mangino; C B Anderson; M K Murphy; E Brunt; J Turk
Journal:  Am J Physiol       Date:  1989-08

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Authors:  M A Gross; D E Viders; J M Brown; D W Mulvin; R H Miles; E R Brentlinger; S E Velasco; T S Crawford; L K Burton; J E Repine
Journal:  Surgery       Date:  1989-08       Impact factor: 3.982

6.  Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

Authors:  L M Colletti; D G Remick; G D Burtch; S L Kunkel; R M Strieter; D A Campbell
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

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Authors:  S Suzuki; L H Toledo-Pereyra; F J Rodriguez; D Cejalvo
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Authors:  C M Grum; R G Fiddian-Green; G L Pittenger; B J Grant; E D Rothman; D R Dantzker
Journal:  J Appl Physiol Respir Environ Exerc Physiol       Date:  1984-04

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Authors:  M Kainuma; K Nakashima; I Sakuma; M Kawase; T Komatsu; Y Shimada; Y Nimura; T Nonami
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  7 in total

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