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Literature DB >> 11508678

A spontaneous nitric oxide donor ameliorates small bowel ischemia-reperfusion injury in dogs.

K Kawata¹, I Takeyoshi, K Iwanami, Y Sunose, M Aiba, S Ohwada, K Matsumoto, Y Morishita.

Abstract

Nitric oxide (NO) appears to play an important role in tissue injury during reperfusion. FK409 is the first spontaneous NO donor that increases plasma guanosine 3',5'-cyclic monophosphate. We investigated the effects of the NO donor FK409 (FK) on ischemia-reperfusion injury in a canine warm ischemia model. Fourteen adult mongrel dogs were divided into two groups: the control group and the FK group, which received FK. The superior mesenteric artery and vein were both clamped for 2 h and then reperfused for 12 h. Arterial and intramucosal pH were well maintained in the FK group in comparison with the control group. Histologically, ischemia-reperfusion injury was significantly more severe in the control group than in the FK group. The serum NO levels were significantly higher in the FK group than in the control group during FK administration. FK409 has protective effects on ischemia-reperfusion injury of the small intestine due to NO release.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2001 PMID： 11508678 DOI： 10.1023/a:1010670008202

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

41 in total

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A spontaneous nitric oxide donor ameliorates small bowel ischemia-reperfusion injury in dogs.

1. Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.

2. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats.

3. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes.

4. Gastric intramucosal pH and hepatic venous oximetry after cardiopulmonary bypass in valve replacement patients.

5. Back-diffusion of CO2 and its influence on the intramural pH in gastric mucosa.

6. FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.

7. Local skin burn causes systemic (lung and kidney) endothelial cell injury reflected by increased circulating and decreased tissue factor VIII-related antigen.

8. Inhaled nitric oxide after lung ischemia reperfusion; effect on hemodynamics and oxygen free radical scavenger system.

9. The reaction of no with superoxide.

10. Adequacy of tissue oxygenation in intact dog intestine.

1. The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.

2. Protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats.

Review 3. Ischemia-reperfusion injury of the intestine and protective strategies against injury.

Review 4. Small bowel review: Diseases of the small intestine.

5. Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents.