Literature DB >> 10571082

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.

M B Beard1, J C O'Connell, G B Bolger, M D Houslay.   

Abstract

Of the five PDE4D isoenzymes, only the PDE4D4 cAMP specific phosphodiesterase was able to bind to SH3 domains. Only PDE4D4 and PDE4A5, but not any other PDE4A, B, C and D isoforms expressed in rat brain, bound to src, lyn and fyn kinase SH3 domains. Purified PDE4D4 could bind to purified lyn SH3. PDE4D4 and PDE4A5 both exhibited selectivity for binding the SH3 domains of certain proteins. PDE4D4 did not bind to WW domains. We suggest that an important function of the unique N-terminal region of PDE4D4 may be to allow for association with certain SH3 domain-containing proteins.

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Year:  1999        PMID： 10571082     DOI： 10.1016/s0014-5793(99)01335-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.

Authors:  K L Dodge; S Khouangsathiene; M S Kapiloff; R Mouton; E V Hill; M D Houslay; L K Langeberg; J D Scott
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Review 2.  Advances in targeting cyclic nucleotide phosphodiesterases.

Authors:  Donald H Maurice; Hengming Ke; Faiyaz Ahmad; Yousheng Wang; Jay Chung; Vincent C Manganiello
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3.  Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.

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Journal:  J Neurosci       Date:  2016-08-24       Impact factor: 6.167

Review 4.  Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.

Authors:  Vladimir N Uversky
Journal:  Expert Rev Proteomics       Date:  2010-08       Impact factor: 3.940

Review 5.  PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.

Authors:  Miles D Houslay; David R Adams
Journal:  Biochem J       Date:  2003-02-15       Impact factor: 3.857

6.  Intracellular membrane association of the Aplysia cAMP phosphodiesterase long and short forms via different targeting mechanisms.

Authors:  Kun-Hyung Kim; Yong-Woo Jun; Yongsoo Park; Jin-A Lee; Byung-Chang Suh; Chae-Seok Lim; Yong-Seok Lee; Bong-Kiun Kaang; Deok-Jin Jang
Journal:  J Biol Chem       Date:  2014-07-30       Impact factor: 5.157

Review 7.  DISC1-binding proteins in neural development, signalling and schizophrenia.

Authors:  Nicholas J Bradshaw; David J Porteous
Journal:  Neuropharmacology       Date:  2010-12-31       Impact factor: 5.250

8.  Involvement of Src family of kinases and cAMP phosphodiesterase in the luteinizing hormone/chorionic gonadotropin receptor-mediated signaling in the corpus luteum of monkey.

Authors:  Shah B Kunal; Asaithambi Killivalavan; Rudraiah Medhamurthy
Journal:  Reprod Biol Endocrinol       Date:  2012-03-29       Impact factor: 5.211

9.  Computational analysis and prediction of the binding motif and protein interacting partners of the Abl SH3 domain.

Authors:  Tingjun Hou; Ken Chen; William A McLaughlin; Benzhuo Lu; Wei Wang
Journal:  PLoS Comput Biol       Date:  2006-01-27       Impact factor: 4.475

10.  Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

Authors:  Graeme B Bolger; Angela McCahill; Stephen J Yarwood; Michael R Steele; Jim Warwicker; Miles D Houslay
Journal:  BMC Biochem       Date:  2002-08-23       Impact factor: 4.059
  10 in total

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